Do Cholesteryl Ester Transfer Protein Inhibitors Have a Role in the Treatment of Cardiovascular Disease?
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Cardiovascular Drugs"
DOI: 10.1007/s40256-018-00323-3
Abstract: Cholesteryl ester transfer protein (CETP) plays an important role in lipid metabolism and has presented an attractive target for drug development, primarily resting on the hope that CETP inhibition would reduce cardiovascular events through its… read more here.
Keywords: transfer protein; cholesteryl ester; ester transfer;
Identification of antisense transcripts of the microsomal triglyceride transfer protein genes in humans and mice.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.07.069
Abstract: Microsomal triglyceride transfer protein (MTTP) is essential for the assembly and secretion of apoB-containing lipoproteins. Here, we report the presence of genes on the anti-sense strands of the human MTTP and mouse Mttp genes. The… read more here.
Keywords: triglyceride transfer; transfer protein; mttp; mttp as1 ... See more keywords
The role of cholesteryl ester transfer protein expression on endothelial cells: oxidative stress and vascular dysfunction
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.312
Abstract: High-density lipoprotein cholesterol (HDL-C) levels are inversely correlated with development of atherosclerotic coronary heart disease and studies demonstrate that cholesteryl ester transfer protein (CETP) deficiency is associated with markedly increased HDL levels. HDL may exert… read more here.
Keywords: transfer protein; dysfunction; cholesteryl ester; role ... See more keywords
Alterations of lipid metabolism, blood pressure and fatty liver in spontaneously hypertensive rats transgenic for human cholesteryl ester transfer protein
Sign Up to like & getrecommendations! Published in 2020 at "Hypertension Research"
DOI: 10.1038/s41440-020-0401-9
Abstract: Cholesteryl ester transfer protein (CETP) mediates a step in reverse cholesterol transport, which channels cholesterol from peripheral tissues back to the liver. Mice and rats are CETP-deficient species, which assumedly contribute to rodent atherosclerosis resistance.… read more here.
Keywords: transfer protein; spontaneously hypertensive; hypertensive rats; cholesteryl ester ... See more keywords
How cholesteryl ester transfer protein can also be a potential triglyceride transporter
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05449-z
Abstract: CETP transfers cholesteryl esters (CEs) and triglycerides (TGs) between different lipoproteins and came in limelight as a drug-target against CVD. In the search for detailed mechanism of lipid transfer through CETP, enormous effort is devoted… read more here.
Keywords: transfer protein; protein also; cholesteryl ester; transfer ... See more keywords
The crystal structure of human microsomal triglyceride transfer protein
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1903029116
Abstract: Significance This study provides a structure for microsomal triglyceride transfer protein, a key protein in lipid metabolism and transport. Microsomal triglyceride transfer protein is linked to a human disease state, abetalipoproteinemia. The structure helps us… read more here.
Keywords: transfer protein; triglyceride transfer; structure; microsomal triglyceride ... See more keywords
Reliable structural information for rational design of benzoxazole type potential cholesteryl ester transfer protein (CETP) inhibitors through multiple validated modeling techniques
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1552895
Abstract: Abstract The drug design and discovery of lipid modulators is very demanding as no new molecule has entered into the market in the last 35 years. Cholesteryl ester transfer protein (CETP) is a promising target… read more here.
Keywords: transfer protein; benzoxazole; cholesteryl ester; cetp ... See more keywords
Design and development of novel therapeutics for coronary heart disease treatment based on cholesteryl ester transfer protein inhibition – in silico approach
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1630319
Abstract: Abstract Cholesteryl ester transfer protein (CETP) belongs to the group of enzymes which inhibition have the application in the treatment of cardiovascular diseases. This study presents QSAR modeling for a set of compounds acting as… read more here.
Keywords: transfer protein; cholesteryl ester; ester transfer;
Control of electron transfer by protein dynamics in photosynthetic reaction centers
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Biochemistry and Molecular Biology"
DOI: 10.1080/10409238.2020.1810623
Abstract: Abstract Trehalose and glycerol are low molecular mass sugars/polyols that have found widespread use in the protection of native protein states, in both short- and long-term storage of biological materials, and as a means of… read more here.
Keywords: protein; protein dynamics; transfer protein; electron transfer ... See more keywords
Preprint Highlight: ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA- dependent STING signaling.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology of the cell"
DOI: 10.1091/mbc.p22-02-1003
Abstract: Loss-of-function mutations in VPS13C cause familial Parkinson’s disease (PD) and increase the risk to develop the sporadic form of the disease. However, the underlying disease mechanisms remain unclear. It has been previously established that VPS13C… read more here.
Keywords: transfer protein; highlight lysosome; lysosome lipid; vps13c ... See more keywords
α-Tocopherol Restriction Dysregulates Neurogenesis-Related Gene Expression in Brains of Weanling α-Tocopherol Transfer Protein Knockout Mice (P11-134-19).
Sign Up to like & getrecommendations! Published in 2019 at "Current developments in nutrition"
DOI: 10.1093/cdn/nzz048.p11-134-19
Abstract: Objectives Humans with vitamin E (α-tocopherol, αT) deficiency develop neurological disorders. Similarly, α-tocopherol transfer protein knockout (Ttpa-/- ) mice have low vitamin E status and exhibit neurodegeneration with age. Shifts in the transcriptome may precede… read more here.
Keywords: ttpa mice; transfer protein; tocopherol transfer; neurogenesis related ... See more keywords