What connects splicing of transfer RNA precursor molecules with pontocerebellar hypoplasia?
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200130
Abstract: Transfer RNAs (tRNAs) represent the most abundant class of RNA molecules in the cell and are key players during protein synthesis and cellular homeostasis. Aberrations in the extensive tRNA biogenesis pathways lead to severe neurological… read more here.
Keywords: pontocerebellar hypoplasia; transfer rna; connects splicing; rna ... See more keywords
Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis.
Sign Up to like & getrecommendations! Published in 2018 at "Mitochondrion"
DOI: 10.1016/j.mito.2018.10.004
Abstract: Mitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of 22 mt-tRNA genes and… read more here.
Keywords: mitochondrial transfer; fibrosis; ipf sarcoidosis; detection mitochondrial ... See more keywords
Transfer RNA: The molecular demiurge in the origin of biological systems.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2020.02.006
Abstract: Herein, we review recent works on the role that the tRNA molecule played in the early origins of biological systems. tRNAs gave origin to the first genes (mRNA), the peptidyl transferase center (PTC), the 16S… read more here.
Keywords: rna molecular; origin biological; biological systems; demiurge origin ... See more keywords
Transfer RNA-derived small RNA: a Rising Star in Oncology.
Sign Up to like & getrecommendations! Published in 2021 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2021.05.024
Abstract: Transfer RNAs (tRNAs) participate in protein synthesis through delivering amino acids to the ribosome. Nevertheless, recent studies revealed that tRNAs can undergo cleavage by endoribonucleases to generate a heterogeneous class of small RNAs, designated as… read more here.
Keywords: rna derived; derived small; rna; transfer rna ... See more keywords
Identification of transfer RNA-derived fragments and their potential roles in aortic dissection.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.06.039
Abstract: Emerging evidence suggests that majority of the transfer RNA (tRNA)-derived small RNA, including tRNA-derived fragments (tRFs) and tRNA halves (tiRNAs), play a significant role in the molecular mechanisms underlying some human diseases. However, expression of… read more here.
Keywords: roles aortic; trfs tirnas; aortic dissection; transfer rna ... See more keywords
Modifications and functional genomics of human transfer RNA
Sign Up to like & getrecommendations! Published in 2018 at "Cell Research"
DOI: 10.1038/s41422-018-0013-y
Abstract: Transfer RNA (tRNA) is present at tens of millions of transcripts in a human cell and is the most abundant RNA in moles among all cellular RNAs. tRNA is also the most extensively modified RNA with,… read more here.
Keywords: human transfer; functional genomics; transfer rna; cell ... See more keywords
Transfer RNA instability as a stress response in Escherichia coli: Rapid dynamics of the tRNA pool as a function of demand
Sign Up to like & getrecommendations! Published in 2018 at "RNA Biology"
DOI: 10.1080/15476286.2017.1391440
Abstract: ABSTRACT Production of the translation apparatus of E. coli is carefully matched to the demand for protein synthesis posed by a given growth condition. For example, the fraction of RNA polymerases that transcribe rRNA and… read more here.
Keywords: rna instability; trna pool; transfer rna; demand ... See more keywords
Transfer RNA is highly unstable during early amino acid starvation in Escherichia coli
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkw1169
Abstract: Due to its long half-life compared to messenger RNA, bacterial transfer RNA is known as stable RNA. Here, we show that tRNAs become highly unstable as part of Escherichia coli's response to amino acid starvation.… read more here.
Keywords: transfer rna; amino; amino acid; acid starvation ... See more keywords
ANGEL2 is a member of the CCR4 family of deadenylases with 2′,3′-cyclic phosphatase activity
Sign Up to like & getrecommendations! Published in 2020 at "Science"
DOI: 10.1126/science.aba9763
Abstract: Deadenylating RNA molecules Transfer RNA (tRNA) and messenger RNA molecules often acquire a terminal 2′,3′-cyclic phosphate group when processed in the cell. These cyclic phosphates provide attachment points for tRNA ligases and must be removed… read more here.
Keywords: phosphatase; rna; rna molecules; transfer rna ... See more keywords
Differential Expression Profiles and Function Prediction of Transfer RNA-Derived Fragments in High-Grade Serous Ovarian Cancer
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/5594081
Abstract: Background The present study is aimed at providing systematic insight into the composition and expression of transfer RNA (tRNA) derivative transcription in high-grade serous ovarian cancer (HGSOC). Methods tRNA derivative expression profiles in three pairs… read more here.
Keywords: grade serous; high grade; trfs tirnas; transfer rna ... See more keywords
The mitochondrial genomes of sarcoptiform mites: are any transfer RNA genes really lost?
Sign Up to like & getrecommendations! Published in 2018 at "BMC Genomics"
DOI: 10.1186/s12864-018-4868-6
Abstract: BackgroundMitochondrial (mt) genomes of animals typically contain 37 genes for 13 proteins, two ribosomal RNA (rRNA) genes and 22 transfer RNA (tRNA) genes. In sarcoptiform mites, the entire set of mt tRNA genes is present… read more here.
Keywords: genes reported; transfer rna; mitochondrial genomes; sarcoptiform mites ... See more keywords