Cytochrome c Catalyzes the Hydrogen Peroxide‐Assisted Oxidative Desulfuration of 2‐Thiouridines in Transfer RNAs
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DOI: 10.1002/cbic.201700692
Abstract: The 5‐substituted 2‐thiouridines (R5S2Us) present in the first (wobble) position of the anticodon of transfer RNAs (tRNAs) contribute to accuracy in reading mRNA codons and tuning protein synthesis. Previously, we showed that, under oxidative stress… read more here.
Keywords: transfer rnas; hydrogen peroxide; oxidative desulfuration; cyt h2o2 ... See more keywords
Targeted sequencing reveals expanded genetic diversity of human transfer RNAs
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DOI: 10.1080/15476286.2019.1646079
Abstract: ABSTRACT Transfer RNAs are required to translate genetic information into proteins as well as regulate other cellular processes. Nucleotide changes in tRNAs can result in loss or gain of function that impact the composition and… read more here.
Keywords: transfer; trna variation; transfer rnas; targeted sequencing ... See more keywords
Transfer RNAs-derived small RNAs and their application potential in multiple diseases
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DOI: 10.3389/fcell.2022.954431
Abstract: The role of tRNAs is best known as adapter components of translational machinery. According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn is translated into proteins, in which… read more here.
Keywords: trf; multiple diseases; derived small; transfer rnas ... See more keywords
The Clinical Significance of Transfer RNAs Present in Extracellular Vesicles
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DOI: 10.3390/ijms23073692
Abstract: Extracellular vesicles (EVs) are important for intercellular signalling in multi-cellular organisms. However, the role of mature transfer RNAs (tRNAs) and tRNA fragments in EVs has yet to be characterised. This systematic review aimed to identify… read more here.
Keywords: transfer rnas; significance transfer; extracellular vesicles; clinical significance ... See more keywords