Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13718
Abstract: Ecdysteroids are critically important for the formation of the insect exoskeleton. Cholesterol is a precursor of ecdysone and its active form 20‐hydroxyecdysone, but some steps in the ecdysteroid biosynthesis pathway remain unknown. An essential requirement… read more here.
Keywords: isomerase activity; biosynthesis; transferase; ecdysteroid biosynthesis ... See more keywords
Synthetic Phosphodiester‐Linked 4‐Amino‐4‐deoxy‐l‐arabinose Derivatives Demonstrate that ArnT is an Inverting Aminoarabinosyl Transferase
Sign Up to like & getrecommendations! Published in 2019 at "Chembiochem"
DOI: 10.1002/cbic.201900349
Abstract: 4‐Amino‐4‐deoxy‐l‐arabinopyranose (Ara4N) residues have been linked to antibiotic resistance due to reduction of the negative charge in the lipid A and core regions of the bacterial lipopolysaccharide (LPS). To study the enzymatic transfer of Ara4N onto… read more here.
Keywords: amino deoxy; ara4n; transferase; phosphodiester linked ... See more keywords
C3 Transferase Gene Therapy for Continuous RhoA Inhibition.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8612-5_19
Abstract: The identification of RhoA inhibition as a therapeutic target in neurodegenerative diseases and traumatic central nervous system (CNS) injuries has introduced a need to develop tools that effectively modulate intracellular RhoA-dependent signaling. In neurons, the… read more here.
Keywords: rhoa inhibition; gene therapy; transferase; rhoa ... See more keywords
Lentiviral vector-mediated expression of C3 transferase attenuates retinal ischemia and reperfusion injury in rats.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119269
Abstract: AIMS Our previous study showed that intravitreal delivery of self-complementary AAV2 (scAAV2)-mediated exoenzyme C3 transferase (C3) can attenuate retinal ischemia/reperfusion (I/R) injury. The current study investigated the neuroprotective effects of lentivirus (LV)-mediated C3 transgene expression… read more here.
Keywords: retinal ischemia; transferase; expression; ischemia reperfusion ... See more keywords
A genome-wide CRISPR screen identifies N-acetylglucosamine-1-phosphate transferase as a potential antiviral target for Ebola virus
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-018-08135-4
Abstract: There are no approved therapies for Ebola virus infection. Here, to find potential therapeutic targets, we perform a screen for genes essential for Ebola virus (EBOV) infection. We identify GNPTAB, which encodes the α and… read more here.
Keywords: gnptab; infection; transferase; ebola virus ... See more keywords
Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209597119
Abstract: Significance N-degron pathways target proteins for degradation by recognizing their N-terminal residues. A destabilizing N-terminal Arg residue can be generated by a proteolytic cleavage of a protein either directly or after N-terminal arginylation of the… read more here.
Keywords: structure ate1; degron; protein; transferase ... See more keywords
Gamma‐Glutamyl Transferase (γ‐GT) – an old dog with new tricks?
Sign Up to like & getrecommendations! Published in 2021 at "Liver International"
DOI: 10.1111/liv.15099
Abstract: Gamma‐Glutamyl Transferase (γGT) is a key transferase involved in the transpeptidation of functional gamma‐glutamyl groups to various receptor moieties. It performs important roles in antioxidant defence mechanisms, particularly glutathione recycling, xenobiotic metabolism, but analogously may… read more here.
Keywords: transferase old; old dog; glutamyl transferase; dog new ... See more keywords
Reversal of hypermethylation and reactivation of glutathione S-transferase pi 1 gene by curcumin in breast cancer cell line
Sign Up to like & getrecommendations! Published in 2017 at "Tumor Biology"
DOI: 10.1177/1010428317692258
Abstract: One of the mechanisms for epigenetic silencing of tumor suppressor genes is hypermethylation of cytosine residue at CpG islands at their promoter region that contributes to malignant progression of tumor. Therefore, activation of tumor suppressor… read more here.
Keywords: glutathione transferase; transferase; curcumin; breast cancer ... See more keywords
Characterization of Xi-class mycothiol S-transferase from Corynebacterium glutamicum and its protective effects in oxidative stress
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell Factories"
DOI: 10.1186/s12934-019-1232-8
Abstract: BackgroundOxidative stress caused by inevitable hostile conditions during fermentative process was the most serious threat to the survival of the well-known industrial microorganism Corynebacterium glutamicum. To survive, C. glutamicum developed several antioxidant defenses including millimolar… read more here.
Keywords: mstx; transferase; class; glutamicum ... See more keywords
Identification of the S-transferase like superfamily bacillithiol transferases encoded by Bacillus subtilis
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0192977
Abstract: Bacillithiol is a low molecular weight thiol found in Firmicutes that is analogous to glutathione, which is absent in these bacteria. Bacillithiol transferases catalyze the transfer of bacillithiol to various substrates. The S-transferase-like (STL) superfamily… read more here.
Keywords: bacillus subtilis; transferase like; bacillithiol transferases; transferase ... See more keywords
Possible Metsulfuron Herbicide Detoxification by a Oryza sativa L. Glutathione S-transferase Enzyme.
Sign Up to like & getrecommendations! Published in 2020 at "Brazilian Archives of Biology and Technology"
DOI: 10.1590/1678-4324-2020180571
Abstract: Rice (Oryza sativa L.) is one of the most important crops in the world, and it is considered the primary source of nutritional layout in developing countries in Asia. The glutathione S-transferases (GSTs) superfamily confers… read more here.
Keywords: transferase; herbicide; oryza sativa; possible metsulfuron ... See more keywords