Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS-p38 signaling axis in senescent cells.
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DOI: 10.1039/d2cc05278d
Abstract: Most of the known senolytics are anti-cancer drugs or their derivative molecules. However, senolytics derived from the active ingredients of traditional Chinese medicine (TCM) are rarely reported. Here, we identified oridonin as a novel senolytic… read more here.
Keywords: ros p38; glutathione transferases; activate ros; transferases activate ... See more keywords