Natural T‐cell ligands that are created by genetic variants can be transferred between cells by extracellular vesicles
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201747152
Abstract: CD4 T cells play a central role as helper cells in adaptive immunity. Presentation of exogenous antigens in MHC class II by professional antigen‐presenting cells is a crucial step in induction of specific CD4 T… read more here.
Keywords: extracellular vesicles; transferred cells; genetic variants; ligands created ... See more keywords
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-12901-3
Abstract: Interleukin-2 (IL-2) is a component of most protocols of adoptive cell transfer (ACT) therapy for cancer, but is limited by short exposure and high toxicities. NKTR-214 is a kinetically-engineered IL-2 receptor βγ (IL-2Rβγ)-biased agonist consisting… read more here.
Keywords: nktr 214; transferred cells; act; adoptively transferred ... See more keywords