High-resolution capillary zone electrophoresis and mass spectrometry for distinction of undersialylated and hypoglycosylated transferrin glycoforms in body fluids.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of separation science"
DOI: 10.1002/jssc.201900857
Abstract: High-resolution capillary zone electrophoresis is used to distinguish transferrin glycoforms present in human serum, cerebrospinal fluid and serum treated with neuraminidase and N-glycosidase F. The obtained data are compared to mass spectrometry data from the… read more here.
Keywords: mass spectrometry; zone electrophoresis; transferrin; capillary zone ... See more keywords
Low-toxicity transferrin-guided polymersomal doxorubicin for potent chemotherapy of orthotopic hepatocellular carcinoma in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2019.05.034
Abstract: Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies. The current chemotherapy with typically low tumor uptake and high toxicity reveals a poor anti-HCC efficacy. Here, we report transferrin-guided polycarbonate-based polymersomal doxorubicin (Tf-Ps-Dox) as… read more here.
Keywords: hepatocellular carcinoma; hcc; dox; polymersomal doxorubicin ... See more keywords
Evolutionary conservation of transferrin genomic organization and expression characterization in seven freshwater turtles.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.168
Abstract: Serum transferrin (tf), encoding an iron-binding glycoprotein, has been revealed to play important roles in iron transportation and immune response, and it also has been demonstrated to be valuable for phylogenetic analysis in vertebrates. However,… read more here.
Keywords: seven freshwater; expression; transferrin genes; evolutionary conservation ... See more keywords
Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Blood reviews"
DOI: 10.1016/j.blre.2017.07.005
Abstract: As the main iron transporter, transferrin delivers iron to target tissues like the bone marrow for erythropoiesis. Also, by binding free iron, transferrin prevents formation of reactive oxygen species. Transferrin deficiency due to congenital hypotransferrinemia… read more here.
Keywords: therapeutic use; modulate; free iron; conditions iron ... See more keywords
Efficient neuronal targeting and transfection using RVG and transferrin-conjugated liposomes
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.146738
Abstract: Effective transport of therapeutic nucleic acid to brain has been a challenge for the success of gene therapy for treating brain diseases. In this study, we proposed liposomal nanoparticles modified with brain targeting ligandsfor active… read more here.
Keywords: targeting transfection; neuronal targeting; efficient neuronal; transferrin ... See more keywords
Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2016.12.008
Abstract: Abstract Intracellular retinal iron accumulation has been implicated in the pathogenesis of age‐related macular degeneration (AMD), the leading cause of irreversible blindness among individuals over the age of 50. Ceruloplasmin/hephaestin double knockout mice (Cp/Heph DKO)… read more here.
Keywords: zip8 zip14; retinal iron; zip14; iron ... See more keywords
Determining the glycation site specificity of human holo-transferrin.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of inorganic biochemistry"
DOI: 10.1016/j.jinorgbio.2018.05.016
Abstract: Understanding the effect of glycation on the function of transferrin, the systemic iron transporter, is fundamental to fully grasp the mechanisms leading to the loss of iron homeostasis observed in diabetes mellitus (DM). The spontaneous… read more here.
Keywords: biochemistry; holo transferrin; glycation; site specificity ... See more keywords
Investigating the relationship between iron and depression.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2017.07.006
Abstract: Lower levels of circulating iron have been associated with depression. Our objective was to investigate the phenotypic and genetic relationship between measures of circulating levels of iron (serum iron, transferrin, transferrin saturation, and ferritin) and… read more here.
Keywords: depression; iron depression; relationship iron; iron ... See more keywords
Exploring the molecular interactions of Galantamine with human Transferrin: In-silico and in vitro insight
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.116227
Abstract: Abstract The iron transporter protein, Transferrin (Tf), is a glycoprotein that binds and mediates the Iron (Fe) transport through blood plasma. It has a significant role in transporting Fe in the endosomal compartment of the… read more here.
Keywords: transferrin; exploring molecular; molecular interactions; interactions galantamine ... See more keywords
A Rationally Designed Complex Replenishes the Transferrin Iron Pool Directly and with High Specificity.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00123
Abstract: Many forms of anemia are caused or complicated by pathologic restriction of iron (Fe). Chronic inflammation and certain genetic mutations decrease the activity of ferroportin, the only Fe-exporter protein, so that endogenously recycled or nutritionally… read more here.
Keywords: transferrin; iron; bbg; chemistry ... See more keywords
Incorporation of transuranium elements: coordination of Cm(iii) to human serum transferrin.
Sign Up to like & getrecommendations! Published in 2018 at "Dalton transactions"
DOI: 10.1039/c8dt02915f
Abstract: The coordination environment of Cm(iii) bound at the Fe(iii) binding sites of transferrin was investigated using a combined experimental and theoretical approach. Complexation studies with two hTf/2N single point mutants, Y95F (Tyr → Phe) and… read more here.
Keywords: coordination; binding site; transuranium elements; incorporation transuranium ... See more keywords