Myotonic dystrophy kinase‐related CDC42‐binding kinase α, a new transferrin receptor type 2‐binding partner, is a regulator of erythropoiesis
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26104
Abstract: Efficient erythropoiesis relies on the expression of the transferrin receptor type 2 (TFR2). In erythroid precursors, TFR2 facilitates the export of the erythropoietin receptor (EPOR) to cell surface, which ensures the survival and proliferation of… read more here.
Keywords: kinase; transferrin receptor; receptor type; myotonic dystrophy ... See more keywords
Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26673
Abstract: β‐thalassemia is a genetic disorder caused by mutations in the β‐globin gene, and characterized by anemia, ineffective erythropoiesis and iron overload. Patients affected by the most severe transfusion‐dependent form of the disease (TDT) require lifelong… read more here.
Keywords: transfusion dependent; deletion; iron; transferrin receptor ... See more keywords
Use of a solid‐state nanopore for profiling the transferrin receptor protein and distinguishing between transferrin receptor and its ligand protein
Sign Up to like & getrecommendations! Published in 2022 at "ELECTROPHORESIS"
DOI: 10.1002/elps.202200147
Abstract: A nanopore device is capable of providing single‐molecule level information of an analyte as they translocate through the sensing aperture—a nanometer‐sized through‐hole—under the influence of an applied electric field. In this study, a silicon nitride… read more here.
Keywords: ligand protein; receptor protein; transferrin receptor; solid state ... See more keywords
Transferrin receptor 1 ablation in satellite cells impedes skeletal muscle regeneration through activation of ferroptosis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12700
Abstract: Satellite cells (SCs) are critical to skeletal muscle regeneration. Inactivation of SCs is linked to skeletal muscle loss. Transferrin receptor 1 (Tfr1) is associated with muscular dysfunction as muscle‐specific deletion of Tfr1 results in growth… read more here.
Keywords: skeletal muscle; muscle regeneration; muscle; transferrin receptor ... See more keywords
Selection for Anti-transferrin Receptor Bispecific T-cell Engager in Different Molecular Formats
Sign Up to like & getrecommendations! Published in 2020 at "Current Medical Science"
DOI: 10.1007/s11596-020-2143-y
Abstract: Selecting an ideal molecular format from diverse structures is a major challenge in developing a bispecific antibody (BsAb). To choose an ideal format of anti-CD3 × anti-transferrin receptor (TfR) bispecific antibodies for clinical application, we… read more here.
Keywords: chain; bispecific cell; anti transferrin; cell engager ... See more keywords
Implication of soluble transferrin receptor and ferritin ratio in gestational diabetes
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-017-0571-4
Abstract: Ferritin provides a good estimate of body iron stores, but loses its significance during systemic inflammation, a defining feature of insulin resistance (IR). On the other hand, serum transferrin receptor protein (sTfR) represents true iron… read more here.
Keywords: gestational diabetes; transferrin receptor; ferritin; gdm ... See more keywords
Structural analysis of the transferrin receptor multifaceted ligand(s) interface.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2019.106242
Abstract: The transferrin receptor 1 (TfR1) is one of the key regulators of iron homeostasis for most higher organisms. It mediates cellular iron import through a constitutive clathrin-dependent endocytosis mechanism and by recruiting iron- regulator proteins… read more here.
Keywords: analysis transferrin; transferrin receptor; receptor multifaceted; receptor ... See more keywords
Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.05.009
Abstract: Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has long been believed to be negatively regulated by a yet-unidentified endonuclease. Here, we show that… read more here.
Keywords: iron homeostasis; degradation; transferrin receptor; iron ... See more keywords
Structure prediction of transferrin receptor protein 1 (TfR1) by homology modelling, docking, and molecular dynamics simulation studies
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03221
Abstract: Transferrin receptor protein 1 (TfR1) is an important molecule in anti-cancer therapy. Targeted delivery of such therapeutic compounds improves their cellular uptake and circulation time, thereby enhancing therapeutic efficacy. Drug designing is therefore used to… read more here.
Keywords: protein; tfr1; molecular dynamics; transferrin receptor ... See more keywords
Targeting the transferrin receptor for brain drug delivery
Sign Up to like & getrecommendations! Published in 2019 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2019.101665
Abstract: Obtaining efficient drug delivery to the brain remains the biggest challenge for the development of therapeutics to treat diseases of the central nervous system. The main obstacle is the blood-brain barrier (BBB), which impedes the… read more here.
Keywords: drug; drug delivery; brain drug; transferrin receptor ... See more keywords
Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00768
Abstract: The presence of the blood–brain barrier (BBB) creates a nigh-on impenetrable obstacle for large macromolecular therapeutics that need to be delivered to the brain milieu to treat neurological disorders. To overcome this, one of the… read more here.
Keywords: bbb; transcytosis; cell bbb; brain ... See more keywords