NFS-22. INVESTIGATING MALIGNANT TRANSFORMATION IN NF1 PEDIATRIC GLIOMAS USING AN IPSCS-DERIVED CEREBRAL ORGANOID MODEL
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae064.580
Abstract: Abstract BACKGROUND Neurofibromatosis Type 1 (NF1) is an autosomal dominant tumor predisposition syndrome affecting 1 in 3000 children around the world. Although NF1 inactivation is recognized as the cause of low-grade glioma (LGG) development, little… read more here.
Keywords: gliomas; malignant transformation; transformation nf1; organoid model ... See more keywords
Malignant transformation of NF1-associated spinal astrocytoma with loss of ATRX expression during the course: A case report.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical neuropathology"
DOI: 10.5414/np301314
Abstract: Few cases of malignant transformation of supposedly low-grade gliomas were described in patients with neurofibromatosis type 1 (NF1). A 27-year-old man with NF1 presented with weakness of his lower extremities and was radiologically found to… read more here.
Keywords: malignant transformation; transformation nf1; loss atrx; tumor ... See more keywords