Selective killing of transformed cells by mechanical stretch.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120866
Abstract: Cancer cells differ from normal cells in several important features like anchorage independence, Warburg effect and mechanosensing. Further, in recent studies, they respond aberrantly to external mechanical distortion. Consistent with altered mechano-responsiveness, we find that… read more here.
Keywords: transformed cells; normal cells; selective killing; tumor cells ... See more keywords
ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101327
Abstract: Summary Previous studies have revealed that, at the initial step of carcinogenesis, transformed cells are often eliminated from epithelia via cell competition with the surrounding normal cells. In this study, we performed cell competition-based high-throughput… read more here.
Keywords: transformed cells; via cell; cell competition; plx4720 ... See more keywords
Protection from Cr(VI)‐induced malignant cell transformation and tumorigenesis of Cr(VI)‐transformed cells by luteolin through Nrf2 signaling
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.04.016
Abstract: &NA; Cr(VI) is a well known environmental carcinogen, but its mechanism of action and the measures required to mitigate its effects remain to be investigated. Our previous studies showed that exposure of human bronchial epithelial… read more here.
Keywords: transformed cells; tumorigenesis; cell; transformation ... See more keywords
N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells.
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2018.04.018
Abstract: N6-methyladenosine (m6A) modification is implicated to play an important role in cellular biological processes, but its regulatory mechanisms in arsenite-induced carcinogenesis are largely unknown. Here, human bronchial epithelial (HBE) cells were chronically treated with 2.5 μM… read more here.
Keywords: transformed cells; arsenite transformed; proliferation apoptosis; cellular proliferation ... See more keywords
ADAM-like Decysin-1 (ADAMDEC1) is a positive regulator of Epithelial Defense Against Cancer (EDAC) that promotes apical extrusion of RasV12-transformed cells
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27469-z
Abstract: Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelia via cell competition with the surrounding normal epithelial cells. However, it remains unknown whether and how soluble factors are involved in… read more here.
Keywords: transformed cells; adam like; apical extrusion; cancer ... See more keywords
Downregulation of hedgehog-interacting protein (HHIP) contributes to hexavalent chromium-induced malignant transformation of human bronchial epithelial cells.
Sign Up to like & getrecommendations! Published in 2020 at "Carcinogenesis"
DOI: 10.1093/carcin/bgaa085
Abstract: Hexavalent chromium [Cr(VI)] is a potent human lung carcinogen. Multiple mechanisms have been proposed that contribute to Cr(VI)-induced lung carcinogenesis including oxidative stress, DNA damage, genomic instability, and epigenetic modulation. However, the molecular mechanisms and… read more here.
Keywords: transformed cells; hedgehog interacting; hhip; hexavalent chromium ... See more keywords
A Tale of Two States: Normal and Transformed, With and Without Rigidity Sensing.
Sign Up to like & getrecommendations! Published in 2019 at "Annual review of cell and developmental biology"
DOI: 10.1146/annurev-cellbio-100818-125227
Abstract: For many years, major differences in morphology, motility, and mechanical characteristics have been observed between transformed cancer and normal cells. In this review, we consider these differences as linked to different states of normal and… read more here.
Keywords: rigidity sensing; transformed cells; biology; normal transformed ... See more keywords
Pan-Aurora Kinase Inhibitor Danusertib Induces Apoptosis of Epstein–Barr Virus-transformed B-Cells Through Caspase and Endoplasmic Reticulum Stress Signaling
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.16033
Abstract: Abstract Background/Aim: Evidence for the relevance of Epstein–Barr virus (EBV) in various types of cancer has expanded; however, the definitive mechanism of EBV-induced oncogenesis remains ambiguous. The purpose of this study was to identify the… read more here.
Keywords: ebv transformed; danusertib; transformed cells; aurora kinase ... See more keywords
Long Non-Coding RNA MEG3 in Metal Carcinogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Toxics"
DOI: 10.3390/toxics11020157
Abstract: Most transcripts from human genomes are non-coding RNAs (ncRNAs) that are not translated into proteins. ncRNAs are divided into long (lncRNAs) and small non-coding RNAs (sncRNAs). LncRNAs regulate their target genes both transcriptionally and post-transcriptionally… read more here.
Keywords: cell; transformed cells; meg3 metal; meg3 ... See more keywords