Promoting High-Value Practice by Reducing Unnecessary Transfusions With a Patient Blood Management Program
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2017.6369
Abstract: Although blood transfusion is a lifesaving therapy for some patients, transfusion has been named 1 of the top 5 overused procedures in US hospitals. As unnecessary transfusions only increase risk and cost without providing benefit,… read more here.
Keywords: patient blood; blood management; transfusion; blood ... See more keywords
Evaluation of the Association of Platelet Count, Mean Platelet Volume, and Platelet Transfusion With Intraventricular Hemorrhage and Death Among Preterm Infants
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.37588
Abstract: Key Points Question What are the associations of platelet transfusion, platelet count (PC), and mean platelet volume (MPV) with intraventricular hemorrhage (IVH) and mortality in preterm infants? Findings In this cohort study of 1221 preterm… read more here.
Keywords: count mean; platelet transfusion; preterm infants; platelet ... See more keywords
Association of Prehospital Transfusion With Mortality in Pediatric Trauma.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA pediatrics"
DOI: 10.1001/jamapediatrics.2023.1291
Abstract: Importance Optimal hemostatic resuscitation in pediatric trauma is not well defined. Objective To assess the association of prehospital blood transfusion (PHT) with outcomes in injured children. Design, Setting, and Participants This retrospective cohort study of… read more here.
Keywords: mortality; cohort; transfusion; pht ... See more keywords
Transfusion and Anemia in Patients Undergoing Vascular Surgery.
Sign Up to like & getrecommendations! Published in 2024 at "JAMA surgery"
DOI: 10.1001/jamasurg.2024.2331
Abstract: This cohort study examines the association between blood transfusion and major adverse cardiovascular events and mortality among people undergoing elective open vascular operations. read more here.
Keywords: surgery; patients undergoing; transfusion; surgery transfusion ... See more keywords
Transfusion‐Related Acute Lung Injury: from Mechanistic Insights to Therapeutic Strategies (Adv. Sci. 11/2025)
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DOI: 10.1002/advs.202570074
Abstract: Transfusion‐Related Acute Lung Injury In this frontispiece, a transfusion bag, Taiji symbol, and alveolar structure highlight the immune imbalance triggered by exogenous blood products, resulting in acute lung injury. Article number 2413364 by Xiaobin Fang… read more here.
Keywords: transfusion related; lung injury; transfusion; acute lung ... See more keywords
The impact of sex on disease phenotype and prognostic thresholds of anemia in myelodysplastic syndromes
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25114
Abstract: To the Editor: Current information on sex-specific genetic (including mutations) and clinical details in myelodysplastic syndromes (MDS) is limited. Similarly, the impact of sex on the use of the conventional 10 g/dl hemoglobin threshold, for… read more here.
Keywords: transfusion; hemoglobin threshold; impact sex; hemoglobin level ... See more keywords
Management of non‐transfusion‐dependent β‐thalassemia (NTDT): The next 5 years
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Hematology"
DOI: 10.1002/ajh.26055
Abstract: To the Editor: Management of patients with β-thalassemia is undergoing a swift evolution, considering the number of novel agents recently receiving marketing approval or entering clinical development. Although (thankfully) the availability of new treatment options… read more here.
Keywords: ineffective erythropoiesis; thalassemia; management; transfusion ... See more keywords
Form follows function for freeze‐dried platelets
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26460
Abstract: Platelets—essential players in hemostasis—represent major challenges in hematology and transfusion medicine. Demand for platelets remains high in many clinical contexts including hematology-oncology, transplant surgery, cardiac surgery, and trauma medicine. Yet, supply from donors is fragile,… read more here.
Keywords: freeze dried; dried platelets; hematology; platelet ... See more keywords
Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26673
Abstract: β‐thalassemia is a genetic disorder caused by mutations in the β‐globin gene, and characterized by anemia, ineffective erythropoiesis and iron overload. Patients affected by the most severe transfusion‐dependent form of the disease (TDT) require lifelong… read more here.
Keywords: transfusion dependent; deletion; iron; transferrin receptor ... See more keywords
Combination of a TGF‐β ligand trap (RAP‐GRL) and TMPRSS6‐ASO is superior for correcting β‐thalassemia
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Hematology"
DOI: 10.1002/ajh.27332
Abstract: A recently approved drug that induces erythroid cell maturation (luspatercept) has been shown to improve anemia and reduce the need for blood transfusion in non‐transfusion‐dependent as well as transfusion‐dependent β‐thalassemia (BT) patients. Although these results… read more here.
Keywords: iron; rap grl; tmprss6 aso; transfusion ... See more keywords
Restrictive vs liberal red blood cell transfusion strategies in patients with acute myocardial infarction and anemia: Rationale and design of the REALITY trial
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cardiology"
DOI: 10.1002/clc.23453
Abstract: Anemia is common in patients with acute myocardial infarction (AMI), and is an independent predictor of mortality. The optimal transfusion strategy in these patients is unclear. read more here.
Keywords: patients acute; myocardial infarction; transfusion; restrictive liberal ... See more keywords