Transfusion‐dependent anemia secondary to vitamin C deficiency
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26484
Abstract: To the Editor: Scurvy, or the syndrome of vitamin C deficiency, is rare in industrialized nations though is still seen in underserved populations and those with risk factors for severe malnutrition. It presents with fatigue,… read more here.
Keywords: anemia; vitamin deficiency; transfusion dependent; vitamin ... See more keywords
Transferrin receptor 2 (Tfr2) genetic deletion makes transfusion‐independent a murine model of transfusion‐dependent β‐thalassemia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26673
Abstract: β‐thalassemia is a genetic disorder caused by mutations in the β‐globin gene, and characterized by anemia, ineffective erythropoiesis and iron overload. Patients affected by the most severe transfusion‐dependent form of the disease (TDT) require lifelong… read more here.
Keywords: transfusion dependent; deletion; iron; transferrin receptor ... See more keywords
Amlodipine: Can act as an antioxidant in patients with transfusion‐dependent β‐thalassemia? A double‐blind, controlled, crossover trial
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24752
Abstract: This study aimed to assess the antioxidant effects of amlodipine in transfusion‐dependent β‐thalassemia (TDT) patients. read more here.
Keywords: dependent thalassemia; act antioxidant; transfusion dependent; amlodipine act ... See more keywords
Efficacy of decitabine as hemoglobin F inducer in HbE/β-thalassemia
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DOI: 10.1007/s00277-018-3357-y
Abstract: To study safety, efficacy (hemoglobin and hemoglobin F percentage increment in non-transfusion-dependent patients and decrease in transfusion frequency in transfusion-dependent patients), and determinants of response of decitabine in patients with HbE/β-thalassemia. Thirty patients of HbE/β-thalassemia… read more here.
Keywords: decitabine; transfusion dependent; hbe thalassemia; hemoglobin ... See more keywords
Alloimmunization and autoimmunization in adult transfusion-dependent thalassemia patients: a report from a comprehensive center in Israel
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DOI: 10.1007/s00277-020-04104-4
Abstract: Patients with beta thalassemia major (TM) are transfusion-dependent (TD) since early childhood and for life. Development of alloantibodies and autoantibodies against red blood cell (RBC) antigens is increasingly recognized as a significant transfusion hazard, especially… read more here.
Keywords: alloimmunization; comprehensive center; transfusion dependent; transfusion ... See more keywords
A high frequency of Gilbert syndrome (UGT1A1*28/*28) and associated hyperbilirubinemia but not cholelithiasis in adolescent and adult north Indian patients with transfusion-dependent β-thalassemia
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DOI: 10.1007/s00277-020-04176-2
Abstract: Hyperbilirubinemia and pigment gallstones are frequent complications in transfusion-dependent β-thalassemia (TDβT) patients. Bilirubin production and clearance are determined by genetic as well as environmental variables like ineffective erythropoiesis, hemolysis, infection-induced hepatic injury, and drug- or… read more here.
Keywords: gilbert syndrome; transfusion dependent; transfusion; total unconjugated ... See more keywords
Pazopanib for severe bleeding and transfusion-dependent anemia in hereditary hemorrhagic telangiectasia
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DOI: 10.1007/s10456-021-09807-4
Abstract: Hereditary hemorrhagic telangiectasia (HHT) is a rare angiogenic disorder causing chronic gastrointestinal bleeding, epistaxis, and severe anemia. Pazopanib is an oral multi-kinase angiogenesis inhibitor with promise to treat bleeding in HHT. We analyzed outcomes of… read more here.
Keywords: pazopanib; severe bleeding; hereditary hemorrhagic; transfusion dependent ... See more keywords
Vitamin C Deficiency and Oxidant Levels in Children With Transfusion-Dependent β-Thalassemia
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DOI: 10.1007/s13312-021-2257-8
Abstract: To study vitamin C levels in children with transfusion-dependent β-thalassemia and correlate with age, transfusions received and iron overload; and to study the effect of administering vitamin C on its levels and Malondialdehyde (MDA) in… read more here.
Keywords: transfusion dependent; vitamin levels; vitamin; deficiency ... See more keywords
Non-Myeloablative Bone Marrow Transplant with Post-Transplant Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Transfusion Dependent Thalassemia: Results of an International Consortium (VGC2)
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DOI: 10.1016/j.bbmt.2019.12.540
Abstract: Background Post-transplant cyclophosphamide (PTCy) enables allogeneic hematopoietic cell transplant (Allo-HCT) across the human leukocyte antigen barrier. Allo-HCT for severe transfusion dependent thalassemia is restricted in its application due to limited donor availability, graft rejection, and… read more here.
Keywords: bone marrow; transfusion dependent; transplant; dependent thalassemia ... See more keywords
Hemoglobin disorders: lentiviral gene therapy in the starting blocks to enter clinical practice.
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DOI: 10.1016/j.exphem.2018.05.004
Abstract: The β-hemoglobinopathies, transfusion-dependent β-thalassemia and sickle cell disease, are the most prevalent inherited disorders worldwide and affect millions of people. Many of these patients have a shortened life expectancy and suffer from severe morbidity despite… read more here.
Keywords: gene therapy; transfusion dependent; gene; cell ... See more keywords
Construction of an exposure-pathway-phenotype in children with depression due to transfusion-dependent thalassemia: Results of (un)supervised machine learning.
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DOI: 10.1016/j.jad.2020.12.089
Abstract: BACKGROUND Transfusion dependent thalassemia (TDT) patients are treated with continued blood transfusions and show a higher prevalence of depression. TDT with consequent iron overload and inflammation is associated with increased severity of depressive symptoms in… read more here.
Keywords: depression; exposure; transfusion dependent; iron overload ... See more keywords