Recruitment of CTCF to an Fto enhancer is responsible for transgenerational inheritance of BPA-induced obesity.
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214988119
Abstract: Significance Exposure of pregnant female mice to bisphenol A (BPA) results in obesity in the F2 progeny, which can be transmitted in the absence of additional exposure up to the F6 generation. Obesity results from… read more here.
Keywords: responsible transgenerational; transgenerational inheritance; ctcf; bpa ... See more keywords
Prenatal Lipopolysaccharides Exposure Induces Transgenerational Inheritance of Hypertension
Sign Up to like & getrecommendations! Published in 2022 at "Circulation"
DOI: 10.1161/circulationaha.122.059891
Abstract: Background: Adverse environmental exposure during the prenatal period can lead to diseases in the offspring, including hypertension. Whether or not the hypertensive phenotype can be transgenerationally transmitted is not known. Methods: Pregnant Sprague Dawley rats… read more here.
Keywords: transgenerational inheritance; induces transgenerational; hypertension; exposure induces ... See more keywords
Mercury-induced epigenetic transgenerational inheritance of abnormal neurobehavior is correlated with sperm epimutations in zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0176155
Abstract: Abstract Methylmercury (MeHg) is a ubiquitous environmental neurotoxicant, with human exposures predominantly resulting from fish consumption. Developmental exposure of zebrafish to MeHg is known to alter their neurobehavior. The current study investigated the direct exposure… read more here.
Keywords: mehg; transgenerational inheritance; generation; sperm epimutations ... See more keywords
Atrazine induced epigenetic transgenerational inheritance of disease, lean phenotype and sperm epimutation pathology biomarkers
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DOI: 10.1371/journal.pone.0184306
Abstract: Ancestral environmental exposures to a variety of environmental toxicants and other factors have been shown to promote the epigenetic transgenerational inheritance of adult onset disease. The current study examined the potential transgenerational actions of the… read more here.
Keywords: transgenerational inheritance; disease; pathology; generation ... See more keywords
Epigenetic Transgenerational Inheritance of the Effects of Obesogen Exposure
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.787580
Abstract: Obesity and metabolic disorders have become a worldwide pandemic affecting millions of people. Although obesity is a multifaceted disease, there is growing evidence supporting the obesogen hypothesis, which proposes that exposure to a subset of… read more here.
Keywords: obesity; exposure; transgenerational inheritance; obesogen exposure ... See more keywords
Impact of Endocrine Disruptors upon Non-Genetic Inheritance
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DOI: 10.3390/ijms23063350
Abstract: Similar to environmental factors, EDCs (endocrine-disrupting chemicals) can influence gene expression without modifying the DNA sequence. It is commonly accepted that the transgenerational inheritance of parentally acquired traits is conveyed by epigenetic alterations also known… read more here.
Keywords: transgenerational inheritance; impact endocrine; disruptors upon; upon non ... See more keywords