In Pursuit of Stability Enhancement of a Prostate Cancer Targeting Antibody Derived from a Transgenic Animal Platform
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66636-z
Abstract: Accelerated timelines necessitate the discovery of fully human antibodies as biotherapeutics using transgenic animals with a notion that such mAbs bypass humanization. A transgenic animal derived mAb (PCa75) targeted against a prostate cancer antigen had… read more here.
Keywords: pursuit stability; stability; transgenic animal; prostate cancer ... See more keywords
Complementary epitopes and favorable developability of monoclonal anti-LAMP1 antibodies generated using two transgenic animal platforms
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0235815
Abstract: Monoclonal antibodies (mAbs) for therapeutic applications should be as similar to native human antibodies as possible to minimize their immunogenicity in patients. Several transgenic animal platforms are available for the generation of fully human mAbs.… read more here.
Keywords: developability; transgenic animal; animal platforms; platforms complementary ... See more keywords
An update on the tools for creating transgenic animal models of human diseases – focus on atherosclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Brazilian Journal of Medical and Biological Research"
DOI: 10.1590/1414-431x20198108
Abstract: Animal models of diseases are invaluable tools of modern medicine. More than forty years have passed since the first successful experiments and the spectrum of available models, as well as the list of methods for… read more here.
Keywords: animal models; update tools; creating transgenic; transgenic animal ... See more keywords
Aged Cattle Brain Displays Alzheimer's Disease-Like Pathology and Promotes Brain Amyloidosis in a Transgenic Animal Model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.815361
Abstract: Alzheimer's disease (AD) is one of the leading causes of dementia in late life. Although the cause of AD neurodegenerative changes is not fully understood, extensive evidence suggests that the misfolding, aggregation and cerebral accumulation… read more here.
Keywords: transgenic animal; alzheimer disease; brain; pathology ... See more keywords