A Simple Guide for Generating BAC Transgenic Animals for Retinal Research.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0175-4_9
Abstract: Bacterial artificial chromosomes (BACs) are genomic tools that can carry several hundred kilobases of exogenous genomic material. This allows to incorporate sufficiently large DNA stretches to include most if not all upstream and downstream cis-regulatory… read more here.
Keywords: transgenic animals; simple guide; bac; bac transgenic ... See more keywords
GFP Transgenic Animals in Biomedical Research: A Review of Potential Disadvantages.
Sign Up to like & getrecommendations! Published in 2019 at "Physiological research"
DOI: 10.33549/physiolres.934227
Abstract: Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals' health. Glomerulosclerosis was… read more here.
Keywords: biomedical research; transgenic animals; animals biomedical; gfp transgenic ... See more keywords
Cruciform DNA Structures Act as Legible Templates for Accelerating Homologous Recombination in Transgenic Animals
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073973
Abstract: Inverted repeat (IR) DNA sequences compose cruciform structures. Some genetic disorders are the result of genome inversion or translocation by cruciform DNA structures. The present study examined whether exogenous DNA integration into the chromosomes of… read more here.
Keywords: cruciform dna; dna; transgenic animals; dna structures ... See more keywords