Homeostatic cytokines tune naivety and stemness of cord blood-derived transgenic T cells.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer gene therapy"
DOI: 10.1038/s41417-021-00395-5
Abstract: Engineered T-cell therapies have proven to be successful in cancer and their clinical effectiveness is directly correlated with the infused T-cell differentiation profile. Indeed, stem cell memory and central memory T cells proliferate and persist… read more here.
Keywords: transgenic cells; derived transgenic; cord blood; naivety stemness ... See more keywords
Abstract A09: GPR64-specific CAR-transgenic T cells selectively kill Ewing sarcoma in vivo
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DOI: 10.1158/1538-7445.pedca17-a09
Abstract: Introduction: Pediatric cancers, including Ewing sarcoma (EwS), are only weakly immunogenic and the tumor patient’s immune system often is devoid of effector T cells for tumor elimination. Based on expression profiling technology, targetable tumor-associated antigens… read more here.
Keywords: gpr64; histology; car transgenic; transgenic cells ... See more keywords
Paving the Way to Solid Tumors: Challenges and Strategies for Adoptively Transferred Transgenic T Cells in the Tumor Microenvironment
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DOI: 10.3390/cancers14174192
Abstract: Simple Summary Adoptive transfer of T cells targeting tumors still remains mainly ineffective in solid entities. In this review we discuss challenges related to the tumor microenvironment (TME) and promising strategies to improve tumor control… read more here.
Keywords: tme; transgenic cells; tumor microenvironment; solid tumors ... See more keywords