Novel short synthetic matrix attachment region for enhancing transgenic expression in recombinant Chinese hamster ovary cells
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DOI: 10.1002/jcb.29165
Abstract: Matrix attachment regions (MARs) are DNA fragments with specific motifs that enhance transgenic expression; however, the characteristics and functions of these elements remain unclear. In this study, we designed and synthesized three short chimeric MARs,… read more here.
Keywords: transgenic expression; hamster ovary; chinese hamster; expression ... See more keywords
Transgenic expression of human CD47 reduces phagocytosis of porcine endothelial cells and podocytes by baboon and human macrophages
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DOI: 10.1111/xen.12549
Abstract: Our initial studies utilizing a galactosyl‐α1‐3‐galactosyltransferase gene knockout (GalTKO) pig‐to‐baboon renal transplant model demonstrated that the early development of nephrotic syndrome has been a significant obstacle to the long‐term survival of baboon recipients. We have… read more here.
Keywords: transgenic expression; cd47; reduces phagocytosis; expression human ... See more keywords
Transgenic expression of fungal accessory hemicellulases in Arabidopsis thaliana triggers transcriptional patterns related to biotic stress and defense response
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DOI: 10.1371/journal.pone.0173094
Abstract: The plant cell wall is an abundant and renewable resource for lignocellulosic applications such as the production of biofuel. Due to structural and compositional complexities, the plant cell wall is, however, recalcitrant to hydrolysis and… read more here.
Keywords: transgenic expression; plant; defense; stress ... See more keywords