Dimethylaminoparthenolide reduces the incidence of dysplasia and ameliorates a wasting syndrome in HPV16‐transgenic mice
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21565
Abstract: The nuclear factor kappa light chain enhancer of activated B cells (NF‐κB) has been implicated in the progression of cancers induced by high‐risk human papillomaviruses (HPV). In cancer patients, NF‐κB is also thought to drive… read more here.
Keywords: syndrome hpv16; transgenic mice; mice; wasting syndrome ... See more keywords
Fat‐1 transgenic mice rich in endogenous omega‐3 fatty acids are protected from lipopolysaccharide‐induced cardiac dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "ESC Heart Failure"
DOI: 10.1002/ehf2.13262
Abstract: Cardiac malfunctions developing in result of sepsis are hard to treat so they eventually contribute to the increased mortality. Previous reports indicated for therapeutic potential of exogenous ω‐3 polyunsaturated fatty acids (PUFA) in sepsis, but… read more here.
Keywords: induced cardiac; mice rich; fatty acids; fat transgenic ... See more keywords
Low molecular weight polysialic acid prevents lipopolysaccharide‐induced inflammatory dopaminergic neurodegeneration in humanized SIGLEC11 transgenic mice
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24073
Abstract: Parkinson's disease is one of the most common neurodegenerative diseases in the elderly population, with a pathophysiology linked to neuroinflammation, complement activation, and oxidative damage. Soluble polysialic acid with an average degree of polymerization 20… read more here.
Keywords: polysia avdp20; transgenic mice; polysia; siglec11 transgenic ... See more keywords
Overexpression of MiR‐335‐5p Promotes Bone Formation and Regeneration in Mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3230
Abstract: MicroRNAs (miRNAs) and the Wnt signaling pathway play critical roles in regulating bone development and homeostasis. Our previous study revealed high expression of miR‐335‐5p in osteoblasts and hypertrophic chondrocytes in mouse embryos and the ability… read more here.
Keywords: bone; mir 335; transgenic mice; bone formation ... See more keywords
Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23137
Abstract: DNA methylation is generally known to inactivate gene expression. The DNA methyltransferases (DNMTs), DNMT3A and DNMT3B, catalyze somatic cell lineage‐specific DNA methylation, while DNMT3A and DNMT3L catalyze germ cell lineage‐specific DNA methylation. How such lineage‐… read more here.
Keywords: methylation; dna; transgenic mice; dnmt3l ... See more keywords
Partial Hepatectomy and Castration of HBV Transgenic Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6700-1_22
Abstract: Hepatitis B virus (HBV) is a hepatotropic virus. Its infection can cause liver injury and regeneration, and its replication is affected by the gender. Transgenic mice that carry a 1.3-mer overlength HBV DNA genome productively… read more here.
Keywords: partial hepatectomy; hbv; transgenic mice; hepatectomy castration ... See more keywords
Detection of Antigen-Specific CD8+ T Cells in the Livers of HCV Core Transgenic Mice.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8976-8_31
Abstract: Hepatitis C virus-mediated immune suppression is an underlying feature leading to the establishment of viral persistence and chronic infection. In particular, HCV core protein has been shown to exhibit significant immunosuppressive activity of T cells… read more here.
Keywords: specific cd8; antigen specific; transgenic mice; core transgenic ... See more keywords
18F-labeled anti-human CD20 cys-diabody for same-day immunoPET in a model of aggressive B cell lymphoma in human CD20 transgenic mice
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4214-x
Abstract: PurposeMetabolic imaging using [18F]FDG is the current standard for clinical PET; however, some malignancies (e.g., indolent lymphomas) show low avidity for FDG. The majority of B cell lymphomas express CD20, making it a valuable target… read more here.
Keywords: pet; cell; transgenic mice; cd20 ... See more keywords
Altered Gut Microbiota Profile in Lin28a Transgenic Mice Can Improve Glucose Tolerance.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05286-1
Abstract: Recent studies showed that gut microbiota can be implicated in the control over glucose metabolism in the host organism. This study employed the Lin28a transgenic mice (Lin28a Tg) characterized by low fasting glucose levels and… read more here.
Keywords: transgenic mice; lin28a transgenic; gut microbiota; mice ... See more keywords
Transgenic Mice Carrying GLUD2 as a Tool for Studying the Expressional and the Functional Adaptation of this Positive Selected Gene in Human Brain Evolution
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2546-3
Abstract: Human evolution is characterized by brain expansion and up-regulation of genes involved in energy metabolism and synaptic transmission, including the glutamate signaling pathway. Glutamate is the excitatory transmitter of neural circuits sub-serving cognitive functions, with… read more here.
Keywords: evolution; human brain; transgenic mice; adaptation ... See more keywords
BAC transgenic mice to study the expression of P2X2 and P2Y1 receptors
Sign Up to like & getrecommendations! Published in 2021 at "Purinergic Signalling"
DOI: 10.1007/s11302-021-09792-9
Abstract: Extracellular purines are important signaling molecules involved in numerous physiological and pathological processes via the activation of P2 receptors. Information about the spatial and temporal P2 receptor (P2R) expression and its regulation remains crucial for… read more here.
Keywords: p2ry1 gene; bac transgenic; transgenic mice; expression ... See more keywords