Gad1‐promotor‐driven GFP expression in non‐GABAergic neurons of the nucleus endopiriformis in a transgenic mouse line
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24673
Abstract: Transgenic animals have become a widely used model to identify and study specific cell types in whole organs. Promotor‐driven reporter gene labeling of the cells under investigation has promoted experimental efficacy to a large degree.… read more here.
Keywords: non gabaergic; mouse line; transgenic mouse; promotor driven ... See more keywords
ScFv-conjugated superparamagnetic iron oxide nanoparticles for MRI-based diagnosis in transgenic mouse models of Parkinson’s and Huntington’s diseases
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.034
Abstract: It is widely accepted that amyloid oligomers are the most toxic species to initiate the pathologic processes of Parkinson's disease (PD) and Huntingdon's disease (HD). But there is no definitive diagnosis for PD and HD… read more here.
Keywords: mouse models; iron oxide; diagnosis; oxide nanoparticles ... See more keywords
Orthodontic force regulates metalloproteinase-3 promoter in osteoblasts and transgenic mouse models
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Sciences"
DOI: 10.1016/j.jds.2021.11.015
Abstract: Background/purpose Previously we demonstrated up-regulation of matrix metalloproteinase-3 (MMP-3) in human osteoblasts under compression and in bony specimens of experimental orthodontic tooth movement (OTM). Here, we studied the temporal characteristics of compression stimulation in human… read more here.
Keywords: mmp promoter; mouse; transgenic mouse; force ... See more keywords
Crush injury to motor nerves in the G93A transgenic mouse model of amyotrophic lateral sclerosis promotes muscle reinnervation and survival of functionally intact nerve-muscle contacts
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.01.019
Abstract: Selective survival of small motor nerve fibers and their neuromuscular contacts in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis (ALS) suggests that smaller regenerated nerve fibers are more able to sustain reformed nerve-muscle… read more here.
Keywords: muscle; nerve fibers; sod1g93a transgenic; transgenic mouse ... See more keywords
Paeoniflorin exerts neuroprotective effects in a transgenic mouse model of Alzheimer’s disease via activation of adenosine A1 receptor
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135016
Abstract: Alzheimer's disease (AD) is the most common cause of dementia, characterised by advanced cognitive and memory deterioration with no effective treatments available. Previous in vitro and in vivo studies suggest that paeoniflorin (PF), a major… read more here.
Keywords: alzheimer disease; transgenic mouse; activation; adenosine ... See more keywords
Increased NK cell immunity in a transgenic mouse model of NKp46 overexpression
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12998-w
Abstract: Natural Killer (NK) cells employ activating receptors like the Natural Cytotoxicity Receptors (NCRs: NKp30, NKp44 and NKp46), of which only NKp46 has a mouse orthologue (Ncr1), to eliminate abnormal cells. NKp46/Ncr1 is considered a selective… read more here.
Keywords: overexpression; cell immunity; increased cell; transgenic mouse ... See more keywords
Behavioural and dopaminergic changes in double mutated human A30P*A53T alpha-synuclein transgenic mouse model of Parkinson´s disease
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-54034-z
Abstract: Alpha-synuclein (aSyn) is the main component of Lewy bodies, the histopathological marker in Parkinson’s disease (PD), and point mutations and multiplications of the aSyn coding SNCA gene correlate with early onset PD. Therefore, various transgenic… read more here.
Keywords: alpha synuclein; a30p a53t; transgenic mouse; parkinson disease ... See more keywords
Generation of a conditional transgenic mouse model expressing human Phospholipase A2 Receptor 1
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-64863-y
Abstract: The Phospholipase A2 Receptor 1 (PLA2R1) was first identified for its ability to bind some secreted PLA2s (sPLA2s). It belongs to the C-type lectin superfamily and it binds different types of proteins. It is likely… read more here.
Keywords: conditional transgenic; transgenic mouse; phospholipase receptor; hpla2r1 ... See more keywords
Viscoelasticity of amyloid plaques in transgenic mouse brain studied by Brillouin microspectroscopy and correlative Raman analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of innovative optical health sciences"
DOI: 10.1142/s1793545817420019
Abstract: Amyloidopathy is one of the most prominent hallmarks of Alzheimer's disease (AD), the leading cause of dementia worldwide, and is characterized by the accumulation of amyloid plaques in the brain parenchyma. The plaques consist of… read more here.
Keywords: amyloid plaques; brain; transgenic mouse; brillouin microspectroscopy ... See more keywords
Abstract 553: SKP2 knockout induces macrophage infiltration in p53/Rb1 null transgenic mouse models of osteosarcoma and drives gene expression correlated with improved survival in patients
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-553
Abstract: Background: Osteosarcoma (OS) is an aggressive cancer of the bone with a poor prognosis. OS often involve mutations of tumor suppressors RB1 and TP53. One putative proto-oncogene in OS is SKP2, which codes for a… read more here.
Keywords: infiltration; skp2; transgenic mouse; knockout ... See more keywords
Analysis of the transgene insertion pattern in a transgenic mouse strain using long-read sequencing
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Animals"
DOI: 10.1538/expanim.19-0118
Abstract: Transgene insertion patterns are critical for the analysis of transgenic animals because the influence of transgenes may change depending on the insertion pattern (such as copy numbers and orientations of concatenations) and the insertion position… read more here.
Keywords: long read; insertion; analysis; transgene insertion ... See more keywords