Comparing BMD‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22137
Abstract: There is growing interest in quantitative analysis of in vivo genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic… read more here.
Keywords: dose response; potency; bmd; transgenic rodent ... See more keywords
Why have transgenic rodent models failed to successfully mimic Alzheimer’s disease. How can we develop effective drugs without them?
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2019.1581169
Abstract: Department of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, Barcelona, Spain; CiberNed: Centro de Investigación en Red, enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain; Departamento de Morfología y Biología Celular,… read more here.
Keywords: biochemistry; asturias spain; models failed; failed successfully ... See more keywords