Protective mechanism of ferulic acid against neomycin‐induced ototoxicity in zebrafish
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23707
Abstract: Ototoxicity refers to damage of sensory hair cells and functional hearing impairment following aminoglycosides exposure. Previously, we have determined that ferulic acid (FA) protected hair cells against serial concentrations of neomycin‐induced ototoxic damage. The aim… read more here.
Keywords: transgenic zebrafish; hair cells; mechanism; ferulic acid ... See more keywords
A Drug-Inducible Transgenic Zebrafish Model for Myelinating Glial Cell Ablation.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9072-6_13
Abstract: To study cellular and molecular mechanisms of demyelination and remyelination in vivo, we developed a transgenic zebrafish line, Tg(mbp:mCherry-NTR), in which expression of the bacterial enzyme nitroreductase (NTR) is driven under the myelin basic protein… read more here.
Keywords: demyelination; mcherry ntr; mbp mcherry; mbp ... See more keywords
Promotion effect of microcystin-LR on liver tumor progression in krasV12 transgenic zebrafish following acute or subacute exposure.
Sign Up to like & getrecommendations! Published in 2021 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2021.112673
Abstract: Microcystin-LR (MC-LR) is widely distributed in the natural environment and causes hepatotoxicity. However, whether MC-LR promotes liver tumor progression remains controversial. krasV12 transgenic zebrafish were used as an inducible liver tumor model to evaluate the… read more here.
Keywords: tumor progression; liver tumor; krasv12 transgenic; progression ... See more keywords
A transgenic zebrafish model for in vivo long-term imaging of retinotectal synaptogenesis
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32409-y
Abstract: The retinotectal synapse in larval zebrafish, combined with live time-lapse imaging, provides an advantageous model for study of the development and remodelling of central synapses in vivo. In previous studies, these synapses were labelled by… read more here.
Keywords: synaptogenesis; zebrafish model; model vivo; stable lines ... See more keywords
Evaluation of qPCR reference genes in GH-overexpressing transgenic zebrafish (Danio rerio)
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69423-y
Abstract: Reference genes (RGs) must have a stable expression in tissues in all experimental conditions to normalize real-time quantitative reverse transcription PCR (qRT-PCR) data. F0104 is a highly studied lineage of zebrafish developed to overexpress the… read more here.
Keywords: qrt pcr; evaluation qpcr; stability; reference genes ... See more keywords
Transgenic zebrafish larvae as a non-rodent alternative model to assess pro-inflammatory (neutrophil) responses to nanomaterials
Sign Up to like & getrecommendations! Published in 2022 at "Nanotoxicology"
DOI: 10.1080/17435390.2022.2088312
Abstract: Abstract Hazard studies for nanomaterials (NMs) commonly assess whether they activate an inflammatory response. Such assessments often rely on rodents, but alternative models are needed to support the implementation of the 3Rs principles. Zebrafish (Danio… read more here.
Keywords: zebrafish larvae; pro inflammatory; inflammatory responses; transgenic zebrafish ... See more keywords
A transgenic zebrafish for in vivo visualization of cilia
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220104
Abstract: Cilia are organelles for cellular signalling and motility. Mutations affecting ciliary function are also associated with cilia-related disorders (ciliopathies). The identification of cilia markers is critical for studying their function at the cellular level. Due… read more here.
Keywords: vivo visualization; transgenic zebrafish; visualization cilia; zebrafish vivo ... See more keywords
Hoxa9/meis1-transgenic zebrafish develops acute myeloid leukaemia-like disease with rapid onset and high penetrance
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.220172
Abstract: HOXA9 and MEIS1 are co-expressed in over 50% of acute myeloid leukaemia (AML) and play essential roles in leukaemogenesis, but the mechanisms involved are poorly understood. Diverse animal models offer valuable tools to recapitulate different… read more here.
Keywords: transgenic zebrafish; acute myeloid; hoxa9; myeloid leukaemia ... See more keywords
Construction of irf4a Transgenic Zebrafish Using Tol2 System and Its Potential Application
Sign Up to like & getrecommendations! Published in 2020 at "Dose-Response"
DOI: 10.1177/1559325820926733
Abstract: Purpose: Interferon regulatory factor 4 (IRF4) is identified as a transcriptional factor and plays an important role in the immune response in mammals; however, there are few reports about the function of zebrafish IRF4. Methods:… read more here.
Keywords: construction irf4a; irf4a transgenic; transgenic zebrafish; zebrafish using ... See more keywords
A transgenic zebrafish model of hepatocyte function in human Z α1-antitrypsin deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Biological Chemistry"
DOI: 10.1515/hsz-2018-0391
Abstract: Abstract In human α1-antitrypsin deficiency, homozygous carriers of the Z (E324K) mutation in the gene SERPINA1 have insufficient circulating α1-antitrypsin and are predisposed to emphysema. Misfolding and accumulation of the mutant protein in hepatocytes also… read more here.
Keywords: human antitrypsin; antitrypsin; zebrafish model; antitrypsin deficiency ... See more keywords
Transfer of the zp3a gene results in changes in egg adhesiveness and buoyancy in transgenic zebrafish
Sign Up to like & getrecommendations! Published in 2023 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2022.330
Abstract: Reproductive strategies and spawning habits play key roles in the evolution of endemic East Asian cyprinids. However, the molecular mechanisms underlying the regulation of spawning habits are not well understood. We recently identified zona pellucida… read more here.
Keywords: east asian; transgenic zebrafish; spawning habits; zp3a gene ... See more keywords