Transient activation of PKC results in long-lasting detrimental effects on systolic [Ca2+]i in cardiomyocytes by altering actin cytoskeletal dynamics and T-tubule integrity.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.01.003
Abstract: AIMS Protein kinase C (PKC) isozymes contribute to the development of heart failure through dysregulation of Ca2+ handling properties and disruption of contractile function in cardiomyocytes. However, the mechanisms by which PKC activation leads to… read more here.
Keywords: pkc activation; ca2; activation; transient activation ... See more keywords
Transient activation of fission yeast AMPK is required for cell proliferation during osmotic stress
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-04-0235
Abstract: Transient activation of the cellular energy sensor AMPK during osmotic stress requires its energy-sensing subunit. Cellular ATP levels decrease during osmotic stress, which triggers energy stress, which in turn requires dynamic activation of AMPK. read more here.
Keywords: activation fission; osmotic stress; stress; transient activation ... See more keywords
Transient activation of spinal trigeminal neurons in a rat model of hypoxia-induced headache.
Sign Up to like & getrecommendations! Published in 2020 at "Pain"
DOI: 10.1097/j.pain.0000000000002114
Abstract: The mechanisms underlying headaches attributed to hypoxia are poorly known. The activation of spinal trigeminal neurons with meningeal afferent input is thought to be responsible for the generation of headaches.In the caudal spinal trigeminal nucleus… read more here.
Keywords: transient activation; trigeminal neurons; spinal trigeminal; activity ... See more keywords
Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aaw0025
Abstract: A transient activation of the unfolded protein response of the ER is a key factor of cellular reprogramming success. Somatic cells can be reprogrammed into pluripotent stem cells using the Yamanaka transcription factors. Reprogramming requires… read more here.
Keywords: essential step; step acquisition; activation uprer; activation ... See more keywords