Transient Competitive Inhibition Bypasses the Binding Site Barrier to Improve Tumor Penetration of Trastuzumab and Enhance T-DM1 Efficacy
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DOI: 10.1158/0008-5472.can-20-3822
Abstract: This study describes the development of a transient competitive inhibition strategy that enhances the tumor penetration and efficacy of anticancer antibodies. Poor penetration of mAbs in solid tumors is explained, in part, by the binding… read more here.
Keywords: transient competitive; efficacy; competitive inhibition; tumor ... See more keywords