Mechanism analysis of transient ligand-induced β-C–H arylation of α-methyl pentanone
Sign Up to like & getrecommendations! Published in 2019 at "Theoretical Chemistry Accounts"
DOI: 10.1007/s00214-019-2523-1
Abstract: Based on a comprehensive DFT mechanism study, the reaction characteristics of β-C–H arylation of α-methyl pentanone with iodobenzene are revealed. In this reaction, glycine plays an important role as organic transient ligand, which can directly… read more here.
Keywords: arylation methyl; transient ligand; methyl pentanone; reaction ... See more keywords
Overcoming peri- and ortho-selectivity in C–H methylation of 1-naphthaldehydes by a tunable transient ligand strategy
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05899a
Abstract: Methyl groups widely exist in bioactive molecules, and site-specific methylation has become a valuable strategy for their structural functionalization. Aiming to introduce this smallest alkyl handle, a highly regioselective peri- and ortho-C–H methylation of 1-naphthaldehyde… read more here.
Keywords: transient ligand; methylation; ligand strategy; strategy ... See more keywords