Celecoxib-Dependent Neuroprotection in a Rat Model of Transient Middle Cerebral Artery Occlusion (tMCAO) Involves Modifications in Unfolded Protein Response (UPR) and Proteasome.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular neurobiology"
DOI: 10.1007/s12035-020-02202-y
Abstract: Stroke is one of the main causes of death and disability worldwide. Ischemic stroke results in unfolded/misfolded protein accumulation in endoplasmic reticulum (ER), a condition known as ER stress. We hypothesized that previously reported neuroprotection… read more here.
Keywords: protein; cerebral artery; celecoxib; middle cerebral ... See more keywords
Up-regulation of sphingosine-1-phosphate receptors and sphingosine kinase 1 in the peri-ischemic area after transient middle cerebral artery occlusion in mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain Research"
DOI: 10.1016/j.brainres.2020.146831
Abstract: There is thought to be a strong relationship between sphingosine-1-phosphate (S1P) signaling and pathophysiolosy of cerebral ischemia. We examined the change of expression and distribution of S1P receptors (S1PRs) and sphingosine kinases (SphKs) after cerebral… read more here.
Keywords: peri; peri infarct; infarct lesion; transient middle ... See more keywords
Investigation of long-term metabolic alteration after stroke in tMCAO (transient middle cerebral artery occlusion) mouse model using metabolomics approach
Sign Up to like & getrecommendations! Published in 2022 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2022.136492
Abstract: Stroke causes serious long-term disability and numerous molecular changes, including inflammation, depression, and immunosuppression. Despite this, the underlying metabolic mechanisms of poststroke complications remain unclear, and assessing metabolic changes may be beneficial. In this study,… read more here.
Keywords: transient middle; long term; term metabolic; term ... See more keywords
Contractile Responses in Spontaneously Hypertensive Rats after Transient Middle Cerebral Artery Occlusion
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DOI: 10.1159/000481570
Abstract: Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the… read more here.
Keywords: cerebral artery; spontaneously hypertensive; middle cerebral; hypertensive rats ... See more keywords
Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion
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DOI: 10.3390/biom9080350
Abstract: It is well known that amyloid beta (Aβ) peptides are generated in blood vessels, released into the brain during thrombosis, and temporarily accumulate in this organ after injury. Here we demonstrate that 24 h after… read more here.
Keywords: cerebral artery; middle cerebral; amyloid beta; transient middle ... See more keywords
Changes in Brain Electrical Activity after Transient Middle Cerebral Artery Occlusion in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Neurology International"
DOI: 10.3390/neurolint14030044
Abstract: Objectives. Ischemic stroke is a leading cause of death and disability worldwide. To search for new therapeutic and pharmacotherapeutic strategies, numerous models of this disease have been proposed, the most popular being transient middle cerebral… read more here.
Keywords: brain; transient middle; middle cerebral; changes brain ... See more keywords
Increased CD68/TGFβ Co-expressing Microglia/ Macrophages after Transient Middle Cerebral Artery Occlusion in Rhesus Monkeys
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Neurobiology"
DOI: 10.5607/en.2019.28.4.458
Abstract: The function of microglia/macrophages after ischemic stroke is poorly understood. This study examines the role of microglia/macrophages in the focal infarct area after transient middle cerebral artery occlusion (MCAO) in rhesus monkeys. We measured infarct… read more here.
Keywords: middle cerebral; transient middle; expressing microglia; microglia macrophages ... See more keywords