F‐ATP synthase and the permeability transition pore: fewer doubts, more certainties
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13485
Abstract: Whether the mitochondrial permeability transition pore (PTP), also called mitochondrial megachannel (MMC), originates from the F‐ATP synthase is a matter of controversy. This hypothesis is supported both by site‐directed mutagenesis of specific residues of F‐ATP… read more here.
Keywords: permeability transition; atp synthase; transition pore;
Sevoflurane postconditioning improves spatial learning and memory ability involving mitochondrial permeability transition pore in hemorrhagic shock and resuscitation rats
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1501
Abstract: Hemorrhagic shock induces the cognitive deficiency. Sevoflurane postconditioning has been documented to provide neuroprotection against ischemic–reperfusion injury by suppressing apoptosis. Mitochondrial permeability transition pore (mPTP) plays an important role in apoptosis, but it is unknown… read more here.
Keywords: sevoflurane postconditioning; hemorrhagic shock; mitochondrial permeability; transition pore ... See more keywords
Alleviation by GABAB Receptors of Neurotoxicity Mediated by Mitochondrial Permeability Transition Pore in Cultured Murine Cortical Neurons Exposed to N-Methyl-d-aspartate
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2311-z
Abstract: Mitochondrial permeability transition pore (PTP) is supposed to at least in part participate in molecular mechanisms underlying the neurotoxicity seen after overactivation of N-methyl-d-aspartate (NMDA) receptor (NMDAR) in neurons. In this study, we have evaluated… read more here.
Keywords: methyl aspartate; nmda; neurotoxicity; mitochondrial permeability ... See more keywords
Phenylglyoxal inhibition of the mitochondrial F1FO-ATPase activated by Mg2+ or by Ca2+ provides clues on the mitochondrial permeability transition pore.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108258
Abstract: Phenylglyoxal (PGO), known to cause post-translational modifications of Arg residues, was used to highlight the role of arginine residues of the F1FO-ATPase, which may be crucial to yield the mitochondrial permeability transition pore (mPTP). In… read more here.
Keywords: f1fo atpase; atpase; ca2; mitochondrial permeability ... See more keywords
Cyclophilin D regulation of the mitochondrial permeability transition pore.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in physiology"
DOI: 10.1016/j.cophys.2022.100486
Abstract: The opening of the mitochondrial permeability transition pore (PTP) has been proposed to play a critical role in activating cell death in many settings, including cardiac ischemia and reperfusion. Although the identity of pore forming… read more here.
Keywords: ptp; transition pore; mitochondrial permeability; permeability transition ... See more keywords
Sirtuin 3 and mitochondrial permeability transition pore (mPTP): a systematic review.
Sign Up to like & getrecommendations! Published in 2022 at "Mitochondrion"
DOI: 10.1016/j.mito.2022.03.004
Abstract: Mitochondrial permeability transition pore (mPTP) is a channel that opens at the inner mitochondrial membrane under conditions of stress. Sirtuin 3 (Sirt3) is a mitochondrial deacetylase known to play a major role in stress resistance… read more here.
Keywords: review; transition pore; sirt3; mitochondrial permeability ... See more keywords
Mitochondrial permeability transition pore in sea urchin female gametes
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of development"
DOI: 10.1016/j.mod.2018.07.008
Abstract: Mitochondrial permeability transition pore (MPTP) has been associated to calcium homeostasis and reactive oxygen species (ROS) generation in several cell types. While extensively investigated in somatic cells, there are few data regarding MPTP phenomenon in… read more here.
Keywords: urchin female; sea; sea urchin; mitochondrial permeability ... See more keywords
Ischemia Injury induces mitochondrial permeability transition pore opening by reducing Sirt3.
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.06.003
Abstract: Mitochondrial permeability transition pore (mPTP) opening is critical to mitochondrial apoptosis during ischemic injury. Sirtuin 3 (Sirt3) is a mitochondrial deacetylase known to play a major role in stress resistance and cell death. Our previous… read more here.
Keywords: mitochondrial permeability; injury; reducing sirt3; transition pore ... See more keywords
Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2020.05.014
Abstract: The mitochondrial permeability transition, an established mechanism for heart diseases, is a long-standing mystery of mitochondrial biology and a prime drug target for cardioprotection. Several hypotheses about its molecular nature have been put forward over… read more here.
Keywords: mitochondrial permeability; permeability; drug target; permeability transition ... See more keywords
Ochratoxin A-Induced Apoptosis of IPEC-J2 Cells through ROS-Mediated Mitochondrial Permeability Transition Pore Opening Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.7b04434
Abstract: With the purpose to explore the mechanisms associated with the intestinal toxicity of Ochratoxin A (OTA), an intestinal porcine epithelial cell line (IPEC-J2) was applied in this study as in vitro models for intestinal epithelium.… read more here.
Keywords: apoptosis; ipec; mitochondrial permeability; ota induced ... See more keywords
Dual dynamics of mitochondrial permeability transition pore opening
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-60177-1
Abstract: Mitochondria play an essential role in bioenergetics and cellular Ca $${}^{2+}$$ 2 + handling. The mitochondrial permeability transition pore (mPTP) is a non-specific channel located in the inner mitochondrial membrane. Long-lasting openings of the pore… read more here.
Keywords: mitochondrial permeability; dual dynamics; transition pore; permeability transition ... See more keywords