Calcium-activated chloride channel TMEM16A opens via pi-helical transition in transmembrane segment 4
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DOI: 10.1073/pnas.2421900122
Abstract: Significance TMEM16A is an anion channel whose main physiological function is to couple chloride conduction to the level of intracellular Ca2+. Despite physiological importance and high pharmacological potential of TMEM16A, its gating mechanism remains incompletely… read more here.
Keywords: channel; helical transition; transition transmembrane; tmem16a ... See more keywords