The roles of RNA processing in translating genotype to phenotype
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2016.139
Abstract: A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA… read more here.
Keywords: processing translating; variants affect; genotype phenotype; translating genotype ... See more keywords
Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Physiology"
DOI: 10.1152/physiol.00009.2016
Abstract: Type 2 diabetes mellitus is a polygenic disease with a variable phenotype. Many genetic associations have been described; however, understanding their underlying pathophysiological role in Type 2 diabetes mellitus is important for development of future… read more here.
Keywords: phenotype; genotype phenotype; disease; obstacles translating ... See more keywords