The RUNX1/RUNX1T1 network: translating insights into therapeutic options
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2020.11.005
Abstract: Highlights • A RUNX1/RUNX1T1-associated gene expression network drives acute myeloid leukemia.• RUNX1/RUNX1T1 dysregulates gene expression at multiple levels.• Interrogation of the RUNX1/RUNX1T1 network by RNA interference or CRISPR screens identifies novel therapeutic targets.• RUNX1/RUNX1T1 drives… read more here.
Keywords: network translating; runx1 runx1t1; runx1t1 network; translating insights ... See more keywords
Translating insights into tumor evolution to clinical practice: promises and challenges
Sign Up to like & getrecommendations! Published in 2019 at "Genome Medicine"
DOI: 10.1186/s13073-019-0632-z
Abstract: Accelerating technological advances have allowed the widespread genomic profiling of tumors. As yet, however, the vast catalogues of mutations that have been identified have made only a modest impact on clinical medicine. Massively parallel sequencing… read more here.
Keywords: medicine; evolution; cancer; tumor evolution ... See more keywords