RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats
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DOI: 10.1038/s41593-019-0455-7
Abstract: Nucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis and frontotemporal dementia. Unconventional translation (RAN translation) of C9orf72 repeats generates dipeptide repeat proteins that can cause neurodegeneration. We… read more here.
Keywords: translation c9orf72; rps25 required; nucleotide repeat; ran translation ... See more keywords