Measuring Translation Efficiency by RNA Immunoprecipitation of Translation Initiation Factors.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1217-0_5
Abstract: Eukaryotic mRNAs are bound by a multitude of RNA binding proteins (RBPs) that control their localization, transport, and translation. Measuring the rate of translation of mRNAs is critical for understanding the factors and pathways involved… read more here.
Keywords: translation efficiency; measuring translation; immunoprecipitation translation; translation ... See more keywords
Comparative analysis of the relationship between translation efficiency and sequence features of endogenous proteins in multiple organisms.
Sign Up to like & getrecommendations! Published in 2021 at "Genomics"
DOI: 10.1016/j.ygeno.2021.05.037
Abstract: The translation efficiency of protein genes is known to be affected by sequence features. Previous studies have found that various sequence features based on codon usage and mRNA secondary structure contribute to translation efficiency. However,… read more here.
Keywords: sequence features; sequence; translation efficiency; relationship translation ... See more keywords
The phosphorylation of carboxyl-terminal eIF2α by SPA kinases contributes to enhanced translation efficiency during photomorphogenesis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-47848-7
Abstract: Light triggers an enhancement of global translation during photomorphogenesis in Arabidopsis, but little is known about the underlying mechanisms. The phosphorylation of the α-subunit of eukaryotic initiation factor 2 (eIF2α) at a conserved serine residue… read more here.
Keywords: eif2; phosphorylation; translation; photomorphogenesis ... See more keywords
Topological and functional characterization of human translation efficiency covariation network
Sign Up to like & getrecommendations! Published in 2025 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btaf583
Abstract: Abstract Motivation Gene co-expression networks based on RNA abundance have identified genes with shared biological functions, common regulatory elements, and physical interactions among their protein products. Although thousands of ribosome profiling datasets are publicly available,… read more here.
Keywords: efficiency covariation; tec network; translation; network ... See more keywords
Leveraging genome-wide datasets to quantify the functional role of the anti-Shine–Dalgarno sequence in regulating translation efficiency
Sign Up to like & getrecommendations! Published in 2017 at "Open Biology"
DOI: 10.1098/rsob.160239
Abstract: Studies dating back to the 1970s established that sequence complementarity between the anti-Shine–Dalgarno (aSD) sequence on prokaryotic ribosomes and the 5′ untranslated region of mRNAs helps to facilitate translation initiation. The optimal location of aSD… read more here.
Keywords: translation efficiency; sequence complementarity; asd sequence; translation ... See more keywords
Translational contributions to tissue specificity in rhythmic and constitutive gene expression
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1222-2
Abstract: BackgroundThe daily gene expression oscillations that underlie mammalian circadian rhythms show striking differences between tissues and involve post-transcriptional regulation. Both aspects remain poorly understood. We have used ribosome profiling to explore the contribution of translation… read more here.
Keywords: translation efficiency; gene expression; expression; gene ... See more keywords
The kpc-1 3′UTR facilitates dendritic transport and translation efficiency of mRNAs for dendrite arborization of a mechanosensory neuron important for male courtship
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011362
Abstract: A recently reported Schizophrenia-associated genetic variant in the 3′UTR of the human furin gene, a homolog of C. elegans kpc-1, highlights an important role of the furin 3′UTR in neuronal development. We isolate three kpc-1… read more here.
Keywords: mechanosensory neuron; utr facilitates; kpc utr; dendrite arborization ... See more keywords
Cap-Independent Circular mRNA Translation Efficiency
Sign Up to like & getrecommendations! Published in 2023 at "Vaccines"
DOI: 10.3390/vaccines11020238
Abstract: Recently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which… read more here.
Keywords: circular mrna; cap independent; mrna translation; translation efficiency ... See more keywords