Manipulation of mRNA translation elongation influences the fragmentation of a biotherapeutic Fc‐fusion protein produced in CHO cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28230
Abstract: Mammalian cells, particularly Chinese hamster ovary cells, are the dominant system for the production of protein‐based biotherapeutics, however, product degradation, particularly of Fc‐fusion proteins, is sometimes observed that impacts the quality of the protein generated.… read more here.
Keywords: fusion; translation elongation; fusion protein; mrna translation ... See more keywords
mRNA‐Independent way to regulate translation elongation rate in eukaryotic cells
Sign Up to like & getrecommendations! Published in 2018 at "IUBMB Life"
DOI: 10.1002/iub.1724
Abstract: The question of what governs the translation elongation rate in eukaryotes has not yet been completely answered. Earlier, different availability of different tRNAs was considered as a main factor involved, however, recent data revealed that… read more here.
Keywords: translation elongation; elongation; rate; rate eukaryotic ... See more keywords
High-Resolution Ribosome Profiling Defines Discrete Ribosome Elongation States and Translational Regulation during Cellular Stress.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.12.009
Abstract: Ribosomes undergo substantial conformational changes during translation elongation to accommodate incoming aminoacyl-tRNAs and translocate along the mRNA template. We used multiple elongation inhibitors and chemical probing to define ribosome conformational states corresponding to differently sized… read more here.
Keywords: translation elongation; stress; ribosome profiling; elongation ... See more keywords
Eukaryotic translation elongation factor 1δ, N-terminal propeptide of type I collagen and cancer-associated fibroblasts are prognostic markers of oral squamous cell carcinoma patients.
Sign Up to like & getrecommendations! Published in 2020 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2020.09.003
Abstract: OBJECTIVE Identifying markers that influence oral squamous cell carcinoma (OSCC) prognosis is a fundamental strategy to improve the overall survival of patients. Markers such as eukaryotic translation elongation factor 1δ (EEF1D), fascin, N-terminal propeptide of… read more here.
Keywords: translation elongation; cell carcinoma; oral squamous; elongation factor ... See more keywords
Sensitivity to an inhibitor of translation elongation in solid and hematologic cancers
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-06273-6
Abstract: Inhibitors of protein synthesis hold promise for cancer therapy because many cancer driver proteins are unstable and blocking synthesis leads to their depletion. We described previously SVC112, a small molecule inhibitor of translation elongation that… read more here.
Keywords: cancer; inhibitor translation; translation; sensitivity ... See more keywords
Insights into the phylogeny of Northern Hemisphere Armillaria: Neighbor-net and Bayesian analyses of translation elongation factor 1-α gene sequences
Sign Up to like & getrecommendations! Published in 2017 at "Mycologia"
DOI: 10.1080/00275514.2017.1286572
Abstract: ABSTRACT Armillaria possesses several intriguing characteristics that have inspired wide interest in understanding phylogenetic relationships within and among species of this genus. Nuclear ribosomal DNA sequence–based analyses of Armillaria provide only limited information for phylogenetic… read more here.
Keywords: translation elongation; neighbor net; armillaria species; northern hemisphere ... See more keywords
Translation Elongation Factor P (EF-P).
Sign Up to like & getrecommendations! Published in 2020 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fuaa003
Abstract: Translation elongation factor P (EF-P) is conserved in all three domains of life (called eIF5A and aIF5A in eukaryotes and archaea, respectively) and functions to alleviate ribosome pausing during the translation of specific sequences, including… read more here.
Keywords: translation elongation; translation; elongation factor;
Codon usage regulates protein structure and function by affecting translation elongation speed in Drosophila cells
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx501
Abstract: Abstract Codon usage biases are found in all eukaryotic and prokaryotic genomes and have been proposed to regulate different aspects of translation process. Codon optimality has been shown to regulate translation elongation speed in fungal… read more here.
Keywords: translation elongation; translation; elongation speed; codon usage ... See more keywords
The translation elongation cycle—capturing multiple states by cryo-electron microscopy
Sign Up to like & getrecommendations! Published in 2017 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2016.0180
Abstract: During the work cycle of elongation, the ribosome, a molecular machine of vast complexity, exists in a large number of states distinguished by constellation of its subunits, its subunit domains and binding partners. Single-particle cryogenic… read more here.
Keywords: translation elongation; microscopy; cycle; electron microscopy ... See more keywords
Identification of an anaplastic subtype of prostate cancer amenable to therapies targeting SP1 or translation elongation
Sign Up to like & getrecommendations! Published in 2024 at "Science Advances"
DOI: 10.1126/sciadv.adm7098
Abstract: Histopathological heterogeneity is a hallmark of prostate cancer (PCa). Using spatial and parallel single-nucleus transcriptomics, we report an androgen receptor (AR)–positive but neuroendocrine-null primary PCa subtype with morphologic and molecular characteristics of small cell carcinoma.… read more here.
Keywords: translation; prostate cancer; sp1 translation; translation elongation ... See more keywords
Altered translation elongation contributes to key hallmarks of aging in the killifish brain.
Sign Up to like & getrecommendations! Published in 2025 at "Science"
DOI: 10.1126/science.adk3079
Abstract: Aging is a major risk factor for neurodegeneration and is characterized by diverse cellular and molecular hallmarks. To understand the origin of these hallmarks, we studied the effects of aging on the transcriptome, translatome, and… read more here.
Keywords: contributes key; brain; altered translation; translation ... See more keywords