Viperin triggers ribosome collision-dependent translation inhibition to restrict viral replication.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cell"
DOI: 10.1016/j.molcel.2022.02.031
Abstract: Innate immune responses induce hundreds of interferon-stimulated genes (ISGs). Viperin, a member of the radical S-adenosyl methionine (SAM) superfamily of enzymes, is the product of one such ISG that restricts the replication of a broad… read more here.
Keywords: viperin triggers; viperin; ribosome collision; translation inhibition ... See more keywords
Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.66369
Abstract: During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5’UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation. The second regulon… read more here.
Keywords: dependent translation; translation; cap dependent; translation inhibition ... See more keywords