CDKAL1 Drives the Maintenance of Cancer Stem‐Like Cells by Assembling the eIF4F Translation Initiation Complex
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206542
Abstract: Cancer stem‐like cells (CSCs) have a unique translation mode, but little is understood about the process of elongation, especially the contribution of tRNA modifications to the maintenance of CSCs properties. Here, it is reported that,… read more here.
Keywords: cdkal1; eif4f translation; initiation complex; translation initiation ... See more keywords
Alternative translation initiation from two in-frame start codons in DHX33 gene.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.05.201
Abstract: DHX33 has been shown to play key roles in promoting cell proliferation. We have previously found that DHX33 protein is a doublet. In this report, we discovered that DHX33 doublet is due to alternative translation… read more here.
Keywords: initiation two; initiation; alternative translation; translation ... See more keywords
The role of eukaryotic translation initiation factor 5A-1 (eIF5A-1) gene in HPV 16 E6 induces cell growth in human cervical squamous carcinoma cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.08.018
Abstract: Human Papillomavirus (HPV) is considered as the major risk factor for the development and progression of cervical cancer. The high expression of HPV 16 E6 may be the causative factor for induction and maintenance of… read more here.
Keywords: carcinoma; initiation factor; hpv; factor ... See more keywords
Critical Roles of Translation Initiation and RNA Uridylation in Endogenous Retroviral Expression and Neural Differentiation in Pluripotent Stem Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107715
Abstract: Previous studies have suggested that the loss of the translation initiation factor eIF4G1 homolog NAT1 induces excessive self-renewability of naive pluripotent stem cells (PSCs); yet the role of NAT1 in the self-renewal and differentiation of… read more here.
Keywords: neural differentiation; differentiation; pluripotent stem; stem cells ... See more keywords
iRQC, a surveillance pathway for 40S ribosomal quality control during mRNA translation initiation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109642
Abstract: Post-translational modification of ribosomal proteins enables rapid and dynamic regulation of protein biogenesis. Site-specific ubiquitylation of 40S ribosomal proteins uS10 and eS10 plays a key role during ribosome-associated quality control (RQC). Distinct, and previously functionally… read more here.
Keywords: 40s ribosomal; initiation; ubiquitylation; translation ... See more keywords
An early nonsense mutation facilitates the expression of a short isoform of CNGA3 by alternative translation initiation
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Eye Research"
DOI: 10.1016/j.exer.2018.02.027
Abstract: Abstract The cyclic nucleotide‐gated (CNG) channel ‐ composed of CNGA3 and CNGB3 subunits ‐ mediates the influx of cations in cone photoreceptors after light stimulation and thus is a key element in cone phototransduction. Mutations… read more here.
Keywords: short isoform; early nonsense; cnga3; isoform ... See more keywords
Mitochondrial mRNA translation initiation contributes to oxidative metabolism in the myocardia of aged, obese mice
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Gerontology"
DOI: 10.1016/j.exger.2019.03.009
Abstract: Abstract Being both advanced in age and obese each contribute to cardiac hypertrophy in a unique manner. Electron transport complexes I and IV are implicated in deficient electron transport during cardiomyopathies and contain the majority… read more here.
Keywords: obese mice; translation initiation; mrna translation; aged obese ... See more keywords
The NS1 Protein from Influenza Virus Stimulates Translation Initiation by Enhancing Ribosome Recruitment to mRNAs.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.04.007
Abstract: The non-structural protein NS1 of influenza A viruses exerts pleiotropic functions during infection. Among these functions, NS1 was shown to be involved in the control of both viral and cellular translation; however, the mechanism by… read more here.
Keywords: ns1 protein; translation; protein influenza; influenza virus ... See more keywords
Metabolic flux of N10-formyltetrahydrofolate plays a critical role in the fidelity of translation initiation in Escherichia coli.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2020.08.003
Abstract: One-carbon metabolism produces methionine and N10-formyl-tetrahydrofolate (N10-fTHF) required for aminoacylation and formylation of initiator tRNA (i-tRNA), respectively. In Escherichia coli, N10-fTHF is made from 5, 10-methylene-THF by a two-step reaction using 5,10-methylene-THF dehydrogenase/cyclohydrolase (FolD). The… read more here.
Keywords: initiation; escherichia coli; fidelity translation; trna ... See more keywords
Regulation of mRNA Translation in Neurons—A Matter of Life and Death
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.09.057
Abstract: Dynamic regulation of mRNA translation initiation and elongation is essential for the survival and function of neural cells. Global reductions in translation initiation resulting from mutations in the translational machinery or inappropriate activation of the… read more here.
Keywords: regulation mrna; death; mrna translation; translation ... See more keywords
Upregulation of eukaryotic translation initiation factor 3 subunit a promotes cell survival in ameloblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Oral surgery, oral medicine, oral pathology and oral radiology"
DOI: 10.1016/j.oooo.2019.02.016
Abstract: OBJECTIVES This study aimed to detect the expression of eukaryotic translation initiation factor 3 subunit a (eIF3a) in ameloblastoma (AB) tissues compared with normal oral mucosa (NOM) tissues and investigate the roles of eIF3a in… read more here.
Keywords: eukaryotic translation; ameloblastoma; translation initiation; factor subunit ... See more keywords