Small molecule RAF265 as an antiviral therapy acts against HSV‐1 by regulating cytoskeleton rearrangement and cellular translation machinery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28226
Abstract: Host‐targeting antivirals (HTAs) have received increasing attention for their potential as broad‐spectrum antivirals that pose relatively low risk of developing drug resistance. The repurposing of pharmaceutical drugs for use as antivirals is emerging as a… read more here.
Keywords: small molecule; translation machinery; molecule raf265; cytoskeleton rearrangement ... See more keywords
HuB serves as the central hub for connecting HuR-related mRNAs with translation machinery in inflammation.
Sign Up to like & getrecommendations! Published in 2025 at "Communications biology"
DOI: 10.1038/s42003-025-09228-9
Abstract: The mRNAs of inflammatory factors often contain unstable AU-rich elements (AREs) within their 3’ untranslated regions (3’UTRs), and HuR is a key ARE-binding protein to recognize such elements. However, the roles of other Hu family… read more here.
Keywords: translation machinery; hub; translation; mrnas translation ... See more keywords
Carrot and stick: how RNase R contributes to function and destruction of the translation machinery
Sign Up to like & getrecommendations! Published in 2025 at "RNA Biology"
DOI: 10.1080/15476286.2025.2535846
Abstract: ABSTRACT RNA is fundamental for life, and its homoeostasis is a critical contributor to cellular growth and adaptation to stress. Key RNA species include messenger RNA (mRNA) and non-coding RNAs, such as transfer RNA (tRNA),… read more here.
Keywords: translation machinery; stick rnase; rna; translation ... See more keywords
Fitness Effects of Phenotypic Mutations at Proteome-Scale Reveal Optimality of Translation Machinery
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msae048
Abstract: Abstract Errors in protein translation can lead to non-genetic, phenotypic mutations, including amino acid misincorporations. While phenotypic mutations can increase protein diversity, the systematic characterization of their proteome-wide frequencies and their evolutionary impact has been… read more here.
Keywords: translation machinery; translation; amino acid; phenotypic mutations ... See more keywords
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging
Sign Up to like & getrecommendations! Published in 2022 at "Genome Research"
DOI: 10.1101/gr.275636.121
Abstract: Reduced provision of protein translation machinery promotes healthy aging in a number of animal models. In humans, however, inborn impairments in translation machinery are a known cause of several developmental disorders, collectively termed ribosomopathies. Here,… read more here.
Keywords: translation machinery; mendelian randomization; human aging; biogenesis translation ... See more keywords
Interactions between the Translation Machinery and Microtubules
Sign Up to like & getrecommendations! Published in 2018 at "Biochemistry (Moscow)"
DOI: 10.1134/s0006297918140146
Abstract: Microtubules are components of eukaryotic cytoskeleton that are involved in the transport of various components from the nucleus to the cell periphery and back. They also act as a platform for assembly of complex molecular… read more here.
Keywords: interactions translation; machinery microtubules; translation machinery; machinery ... See more keywords
The dark side of mRNA translation and the translation machinery in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1086964
Abstract: Among the different types of cancer affecting the central nervous system (CNS), glioblastoma (GB) is classified by the World Health Organization (WHO) as the most common and aggressive CNS cancer in adults. GB incidence is… read more here.
Keywords: dark side; translation machinery; glioblastoma; mrna translation ... See more keywords
The Minimal Translation Machinery: What We Can Learn From Naturally and Experimentally Reduced Genomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.858983
Abstract: The current theoretical proposals of minimal genomes have not attempted to outline the essential machinery for proper translation in cells. Here, we present a proposal of a minimal translation machinery based on (1) a comparative… read more here.
Keywords: translation machinery; learn naturally; minimal translation; machinery learn ... See more keywords