Small molecule RAF265 as an antiviral therapy acts against HSV‐1 by regulating cytoskeleton rearrangement and cellular translation machinery
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28226
Abstract: Host‐targeting antivirals (HTAs) have received increasing attention for their potential as broad‐spectrum antivirals that pose relatively low risk of developing drug resistance. The repurposing of pharmaceutical drugs for use as antivirals is emerging as a… read more here.
Keywords: small molecule; translation machinery; molecule raf265; cytoskeleton rearrangement ... See more keywords
Mendelian randomization analyses implicate biogenesis of translation machinery in human aging
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DOI: 10.1101/gr.275636.121
Abstract: Reduced provision of protein translation machinery promotes healthy aging in a number of animal models. In humans, however, inborn impairments in translation machinery are a known cause of several developmental disorders, collectively termed ribosomopathies. Here,… read more here.
Keywords: translation machinery; mendelian randomization; human aging; biogenesis translation ... See more keywords
Interactions between the Translation Machinery and Microtubules
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DOI: 10.1134/s0006297918140146
Abstract: Microtubules are components of eukaryotic cytoskeleton that are involved in the transport of various components from the nucleus to the cell periphery and back. They also act as a platform for assembly of complex molecular… read more here.
Keywords: interactions translation; machinery microtubules; translation machinery; machinery ... See more keywords
The dark side of mRNA translation and the translation machinery in glioblastoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1086964
Abstract: Among the different types of cancer affecting the central nervous system (CNS), glioblastoma (GB) is classified by the World Health Organization (WHO) as the most common and aggressive CNS cancer in adults. GB incidence is… read more here.
Keywords: dark side; translation machinery; glioblastoma; mrna translation ... See more keywords
The Minimal Translation Machinery: What We Can Learn From Naturally and Experimentally Reduced Genomes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.858983
Abstract: The current theoretical proposals of minimal genomes have not attempted to outline the essential machinery for proper translation in cells. Here, we present a proposal of a minimal translation machinery based on (1) a comparative… read more here.
Keywords: translation machinery; learn naturally; minimal translation; machinery learn ... See more keywords