The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs
Sign Up to like & getrecommendations! Published in 2019 at "Nature Nanotechnology"
DOI: 10.1038/s41565-019-0591-y
Abstract: The regulatory approval of Onpattro, a lipid nanoparticle-based short interfering RNA drug for the treatment of polyneuropathies induced by hereditary transthyretin amyloidosis, paves the way for clinical development of many nucleic acid-based therapies enabled by… read more here.
Keywords: acid based; onpattro story; clinical translation; story clinical ... See more keywords
Challenges associated and approaches for successful translation of nanomedicines into commercial products.
Sign Up to like & getrecommendations! Published in 2017 at "Nanomedicine"
DOI: 10.2217/nnm-2017-0039
Abstract: Nanomedicines are complex engineered nanoscale structures and are widely used in the treatment and targeting of diseases because of their numerous therapeutic benefits. These benefits are: protection of biomolecules from degradation, enhanced solubility and bioavailability,… read more here.
Keywords: approaches successful; challenges associated; translation; successful translation ... See more keywords