Advances and Breakthroughs in IRES-Directed Translation and Replication of Picornaviruses
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DOI: 10.1128/mbio.00358-23
Abstract: The family Picornaviridae is divided into 68 genera and 158 species. The viruses belonging to this family range from public health importance, such as poliovirus, enterovirus A71, and hepatitis A virus, to animal viruses of… read more here.
Keywords: replication; replication picornaviruses; importance; translation replication ... See more keywords
Specific DNAzymes cleave the 300–618 nt of 5′UTR to inhibit DHAV-1 translation and replication
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1064612
Abstract: DNAzymes effectively inhibit the expression of viral genes. Duck hepatitis A virus type-1 (DHAV-1) genomic RNA carries an internal ribosome entry site (IRES). The IRES initiates the translation of DHAV-1 via a mechanism that differs… read more here.
Keywords: designed dnazymes; dhav; 300 618; translation replication ... See more keywords