Translation stress and collided ribosomes are co-activators of cGAS
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.05.018
Abstract: Summary The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway senses cytosolic DNA and induces interferon-stimulated genes (ISGs) to activate the innate immune system. Here, we report the unexpected discovery that cGAS also senses dysfunctional… read more here.
Keywords: cgas; translation stress; stress collided; translation ... See more keywords
A pathway linking translation stress to checkpoint kinase 2 signaling in Neurospora crassa
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1815396116
Abstract: Significance Checkpoint kinase 2 (CHK-2) is a key component of the DNA damage response (DDR) pathway and its activation mechanism is evolutionarily conserved. We show that PERIOD-4 (PRD-4), the CHK-2 ortholog of Neurospora crassa, is… read more here.
Keywords: translation stress; kinase; prd; translation ... See more keywords