Conformational Control of Translation Termination on the 70S Ribosome.
Sign Up to like & getrecommendations! Published in 2018 at "Structure"
DOI: 10.1016/j.str.2018.04.001
Abstract: Translation termination ensures proper lengths of cellular proteins. During termination, release factor (RF) recognizes a stop codon and catalyzes peptide release. Conformational changes in RF are thought to underlie accurate translation termination. However, structural studies… read more here.
Keywords: translation termination; stop codon; termination; codon recognition ... See more keywords
The catalytic activity of the translation termination factor methyltransferase Mtq2-Trm112 complex is required for large ribosomal subunit biogenesis
Sign Up to like & getrecommendations! Published in 2020 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa972
Abstract: Abstract The Mtq2-Trm112 methyltransferase modifies the eukaryotic translation termination factor eRF1 on the glutamine side chain of a universally conserved GGQ motif that is essential for release of newly synthesized peptides. Although this modification is… read more here.
Keywords: mtq2; translation termination; mtq2 trm112;
Mechanisms that ensure speed and fidelity in eukaryotic translation termination
Sign Up to like & getrecommendations! Published in 2021 at "Science"
DOI: 10.1126/science.abi7801
Abstract: How translation stops Protein synthesis concludes when a ribosome encounters a stop codon in a transcript, which triggers the recruitment of highly conserved release factors to liberate the protein product. Lawson et al. used traditional… read more here.
Keywords: release factors; translation; translation termination; termination ... See more keywords
Global analysis of translation termination in E. coli
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DOI: 10.1371/journal.pgen.1006676
Abstract: Terminating protein translation accurately and efficiently is critical for both protein fidelity and ribosome recycling for continued translation. The three bacterial release factors (RFs) play key roles: RF1 and 2 recognize stop codons and terminate… read more here.
Keywords: global analysis; translation; translation termination; stop codons ... See more keywords
Translation termination-dependent deadenylation of MYC mRNA in human cells
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25459
Abstract: The earliest step in the mRNA degradation process is deadenylation, a progressive shortening of the mRNA poly(A) tail by deadenylases. The question of when deadenylation takes place remains open. MYC mRNA is one of the… read more here.
Keywords: poly tail; translation termination; myc mrna; myc ... See more keywords
The structural basis for release-factor activation during translation termination revealed by time-resolved cryogenic electron microscopy.
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DOI: 10.2210/pdb6osq/pdb
Abstract: When the ribosome encounters a stop codon, it recruits a release factor (RF) to hydrolyze the ester bond between the peptide chain and tRNA. RFs have structural motifs that recognize stop codons in the decoding… read more here.
Keywords: translation termination; time; release factor; microscopy ... See more keywords
CTELS: A Cell-Free System for the Analysis of Translation Termination Rate
Sign Up to like & getrecommendations! Published in 2020 at "Biomolecules"
DOI: 10.3390/biom10060911
Abstract: Translation termination is the final step in protein biosynthesis when the synthesized polypeptide is released from the ribosome. Understanding this complex process is important for treatment of many human disorders caused by nonsense mutations in… read more here.
Keywords: analysis; termination rate; translation; translation termination ... See more keywords