Translational Control under Stress: Reshaping the Translatome
Sign Up to like & getrecommendations! Published in 2019 at "BioEssays"
DOI: 10.1002/bies.201900009
Abstract: Adequate reprogramming of cellular metabolism in response to stresses or suboptimal growth conditions involves a myriad of coordinated changes that serve to promote cell survival. As protein synthesis is an energetically expensive process, its regulation… read more here.
Keywords: reshaping translatome; translational control; stress reshaping; stress ... See more keywords
Translational control during poxvirus infection
Sign Up to like & getrecommendations! Published in 2019 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1515
Abstract: Poxviruses are an unusual family of large double‐stranded (ds) DNA viruses that exhibit an incredible degree of self‐sufficiency and complexity in their replication and immune evasion strategies. Indeed, amongst their approximately 200 open reading frames… read more here.
Keywords: poxvirus infection; control; infection; translational control ... See more keywords
Battling for Ribosomes: Translational Control at the Forefront of the Antiviral Response.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.04.040
Abstract: In the early stages of infection, gaining control of the cellular protein synthesis machinery including its ribosomes is the ultimate combat objective for a virus. To successfully replicate, viruses unequivocally need to usurp and redeploy… read more here.
Keywords: response; control; translational control; control forefront ... See more keywords
Translational Control in the Latency of Apicomplexan Parasites.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in parasitology"
DOI: 10.1016/j.pt.2017.08.006
Abstract: Apicomplexan parasites Toxoplasma gondii and Plasmodium spp. use latent stages to persist in the host, facilitate transmission, and thwart treatment of infected patients. Therefore, it is important to understand the processes driving parasite differentiation to… read more here.
Keywords: control; control latency; translational control; apicomplexan parasites ... See more keywords
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03544-x
Abstract: Cleavage of transfer (t)RNA and ribosomal (r)RNA are critical and conserved steps of translational control for cells to overcome varied environmental stresses. However, enzymes that are responsible for this event have not been fully identified… read more here.
Keywords: rrna targeting; rrna; trna rrna; rnase ... See more keywords
Translational control of gene function through optically regulated nucleic acids.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Society reviews"
DOI: 10.1039/d1cs00257k
Abstract: Translation of mRNA into protein is one of the most fundamental processes within biological systems. Gene expression is tightly regulated both in space and time, often involving complex signaling or gene regulatory networks, as most… read more here.
Keywords: nucleic acids; gene function; translational control; function ... See more keywords
Lipid biosynthesis: When the cell cycle meets protein synthesis?
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1312851
Abstract: Cells must tightly coordinate the levels of many of their proteins to navigate accurately and safely the transitions of the cell cycle. For cells to grow and divide, not only proteins but also lipids must… read more here.
Keywords: mitosis; fatty acid; translational control; cell cycle ... See more keywords
Quantitating translational control: mRNA abundance-dependent and independent contributions and the mRNA sequences that specify them
Sign Up to like & getrecommendations! Published in 2017 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkx898
Abstract: Abstract Translation rate per mRNA molecule correlates positively with mRNA abundance. As a result, protein levels do not scale linearly with mRNA levels, but instead scale with the abundance of mRNA raised to the power… read more here.
Keywords: mrna abundance; translation; translational control; mrna ... See more keywords
Translational control in neurovascular brain development
Sign Up to like & getrecommendations! Published in 2021 at "Royal Society Open Science"
DOI: 10.1098/rsos.211088
Abstract: The human brain carries out complex tasks and higher functions and is crucial for organismal survival, as it senses both intrinsic and extrinsic environments. Proper brain development relies on the orchestrated development of different precursor… read more here.
Keywords: control neurovascular; translational control; brain development; brain ... See more keywords
Stress Granules and Processing Bodies in Translational Control.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a032813
Abstract: Stress granules (SGs) and processing bodies (PBs) are non-membrane-enclosed RNA granules that dynamically sequester translationally inactive messenger ribonucleoprotein particles (mRNPs) into compartments that are distinct from the surrounding cytoplasm. mRNP remodeling, silencing, and/or storage involves… read more here.
Keywords: bodies translational; stress granules; processing bodies; translational control ... See more keywords
Corrigendum: A novel translational control mechanism involving RNA structures within coding sequences.
Sign Up to like & getrecommendations! Published in 2017 at "Genome research"
DOI: 10.1101/gr.222133.117
Abstract: The authors would like to correct the omission of a funding number in the Acknowledgments section. The fourth sentence of that paragraph should read as follows: “This work was supported by the Spanish Ministry of… read more here.
Keywords: corrigendum novel; translational control; control mechanism; mechanism involving ... See more keywords