Reprogramming translation for gene therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2021.01.028
Abstract: Translational control plays a fundamental role in the regulation of gene expression in eukaryotes. Modulating translational efficiency allows the cell to fine-tune the expression of genes, spatially control protein localization, and trigger fast responses to… read more here.
Keywords: reprogramming translation; translation; translational efficiency; gene ... See more keywords
Trans-splicing enhances translational efficiency in C. elegans.
Sign Up to like & getrecommendations! Published in 2017 at "Genome research"
DOI: 10.1101/gr.202150.115
Abstract: Translational efficiency is subject to extensive regulation. However, the factors influencing such regulation are poorly understood. In Caenorhabditis elegans, 62% of genes are trans-spliced to a specific spliced leader (SL1), which replaces part of the… read more here.
Keywords: enhances translational; trans spliced; translational efficiency; sl1 trans ... See more keywords
Crosstalk between alternative polyadenylation and miRNAs in the regulation of protein translational efficiency.
Sign Up to like & getrecommendations! Published in 2018 at "Genome research"
DOI: 10.1101/gr.231506.117
Abstract: 3' UTRs play important roles in the gene regulation network via their influence on mRNA stability, translational efficiency, and subcellular localization. For a given gene, 3' UTRs of different lengths generated by alternative polyadenylation (APA)… read more here.
Keywords: translational efficiency; regulation protein; mirnas regulation; alternative polyadenylation ... See more keywords
The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation
Sign Up to like & getrecommendations! Published in 2022 at "RNA"
DOI: 10.1261/rna.079046.121
Abstract: Neurons provide a rich setting for studying post-transcriptional control. Here, we investigate the landscape of translational control in neurons and search for mRNA features that explain differences in translational efficiency (TE), considering the interplay between… read more here.
Keywords: micrornas neuronal; translational efficiency; mrna; control ... See more keywords
Systematic genomic and translational efficiency studies of uveal melanoma
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0178189
Abstract: To further our understanding of the somatic genetic basis of uveal melanoma, we sequenced the protein-coding regions of 52 primary tumors and 3 liver metastases together with paired normal DNA. Known recurrent mutations were identified… read more here.
Keywords: uveal melanoma; mutant eif1ax; translational efficiency; eif1ax ... See more keywords
Multifarious Translational Regulation during Replicative Aging in Yeast
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof8090938
Abstract: Protein synthesis is strictly regulated during replicative aging in yeast, but global translational regulation during replicative aging is poorly characterized. To conduct ribosome profiling during replicative aging, we collected a large number of dividing aged… read more here.
Keywords: translational efficiency; translational regulation; replicative aging; regulation replicative ... See more keywords