Structure of a human 48S translational initiation complex
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DOI: 10.1126/science.aba4904
Abstract: Finding the start Eukaryotic translation involves many players in a dynamic and well-orchestrated process. A 43S preinitiation complex (PIC) comprises the 40S ribosomal subunit; initiation factors, including the eIF3 complex, which is known to play… read more here.
Keywords: initiation; microscopy; initiation complex; human 48s ... See more keywords
Abstract B26: A novel naturally-derived withalonglide synergizes with cisplatin to block self-renewal, migration, and EMT transition to enhance apoptosis via targeting of translational initiation
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DOI: 10.1158/1538-7445.transcontrol16-b26
Abstract: Introduction: Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer in the world with greater than 300,000 fatalities annually. Despite advances in surgery, chemotherapy and radiotherapy, the five-year survival rate of… read more here.
Keywords: wga; treatment; cisplatin; cancer ... See more keywords
Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing
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DOI: 10.7554/elife.55002
Abstract: Shine-Dalgarno (SD) motifs are thought to play an important role in translational initiation in bacteria. Paradoxically, ribosome profiling studies in E. coli show no correlation between the strength of an mRNA’s SD motif and how… read more here.
Keywords: initiation; mrna; translational initiation; initiation coli ... See more keywords