Evidence for co-translational misincorporation of non-canonical amino acid hydroxyproline in recombinant antibodies produced in Chinese Hamster Ovary (CHO) cell lines
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DOI: 10.1371/journal.pone.0241250
Abstract: With the advent of highly sensitive technologies such as tandem mass spectrometry and next-generation sequencing, recombinant antibodies are now routinely analyzed for the presence of low-level sequence variants including amino acid misincorporations. During mAb cell… read more here.
Keywords: translational misincorporation; amino acid; hydroxyproline; non canonical ... See more keywords