Studying Reversible Protein Post‐translational Modification through Co‐translational Modification
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200716
Abstract: Understanding the post‐translational modifications of targeted proteins is of great significance for manipulating the physiological processes of eukaryotes. Chemical biology tools have been used to investigate the biological roles of those post‐translational modifications at particular… read more here.
Keywords: modification; post translational; studying reversible; reversible protein ... See more keywords
Mechanosignaling pathways alter muscle structure and function by post-translational modification of existing sarcomeric proteins to optimize energy usage
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Muscle Research and Cell Motility"
DOI: 10.1007/s10974-021-09596-9
Abstract: A transduced mechanical signal arriving at its destination in muscle alters sarcomeric structure and function. A major question addressed is how muscle mass and tension generation are optimized to match actual performance demands so that… read more here.
Keywords: energy; muscle; post translational; translational modification ... See more keywords
Insights into post-translational modification enzymes from RiPPs: A toolkit for applications in peptide synthesis.
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2022.107908
Abstract: The increasing length and complexity of peptide drug candidates foster the development of novel strategies for their manufacture, which should include sustainable and efficient technologies. In this context, including enzymatic catalysis in the production of… read more here.
Keywords: modification enzymes; enzymes ripps; ripps toolkit; insights post ... See more keywords
Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.01.003
Abstract: Apoptosis is a crucial program of cell death that controls development and homeostasis of multicellular organisms. The main initiators and executors of this process are the Cysteine-dependent ASPartate proteASES - caspases. A number of regulatory… read more here.
Keywords: apoptosis; modification caspases; post translational; translational modification ... See more keywords
Dynamics of Post-Translational Modification Inspires Drug Design in the Kinase Family.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01076
Abstract: Post-translational modification (PTM) on protein plays important roles in the regulation of cellular function and disease pathogenesis. The systematic analysis of PTM dynamics presents great opportunities to enlarge the target space by PTM allosteric regulation.… read more here.
Keywords: post translational; translational modification; drug design; kinase family ... See more keywords
Novel Mussel-Inspired Universal Surface Functionalization Strategy: Protein-Based Coating with Residue-Specific Post-Translational Modification in Vivo.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b22551
Abstract: Surface functionalization can effectively endow materials with desirable properties, promoting the performance between the material and environment, with extensive applications. However, a universal and straightforward surface functionalization method with biocompatibility is scarce. In this study,… read more here.
Keywords: protein; surface; post translational; translational modification ... See more keywords
Bacterial virulence mediated by orthogonal post-translational modification
Sign Up to like & getrecommendations! Published in 2020 at "Nature Chemical Biology"
DOI: 10.1038/s41589-020-0638-2
Abstract: Many bacterial pathogens secrete virulence factors, also known as effector proteins, directly into host cells. These effectors suppress pro-inflammatory host signaling while promoting bacterial infection. A particularly interesting subset of effectors post-translationally modify host proteins… read more here.
Keywords: virulence; post translational; translational modification; chemistry ... See more keywords
Effect of a post-translational modification mimic on protein translocation through a nanopore.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr01577f
Abstract: Post-translational modifications (PTMs) of proteins are recognized as crucial components of cell signaling pathways through modulating folding, altering stability, changing interactions with ligands, and, therefore, serving multiple regulatory functions. PTMs occur as covalent modifications of… read more here.
Keywords: effect post; post translational; translational modification; translocation ... See more keywords
Nitro-oleic acid regulates T cell activation through post-translational modification of calcineurin.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208924120
Abstract: Nitro-fatty acids (NO2-FAs) are unsaturated fatty acid nitration products that exhibit anti-inflammatory actions in experimental mouse models of autoimmune and allergic diseases. These electrophilic molecules interfere with intracellular signaling pathways by reversible post-translational modification of… read more here.
Keywords: post translational; nitro oleic; acid; translational modification ... See more keywords
Accurate Models of Substrate Preferences of Post-Translational Modification Enzymes from a Combination of mRNA Display and Deep Learning
Sign Up to like & getrecommendations! Published in 2022 at "ACS Central Science"
DOI: 10.1101/2022.02.14.480467
Abstract: Promiscuous post-translational modification (PTM) enzymes often display non-obvious substrate preferences by acting on diverse yet well-defined sets of peptides and/or proteins. Thorough understanding of substrate fitness landscapes for promiscuous PTM enzymes is important because they… read more here.
Keywords: post translational; ptm enzymes; substrate preferences; deep learning ... See more keywords
Methionine oxidation in bacteria: A reversible post‐translational modification
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Microbiology"
DOI: 10.1111/mmi.15000
Abstract: Methionine is a sulfur‐containing residue found in most proteins which are particularly susceptible to oxidation. Although methionine oxidation causes protein damage, it can in some cases activate protein function. Enzymatic systems reducing oxidized methionine have… read more here.
Keywords: reversible post; oxidation; post translational; methionine oxidation ... See more keywords