The logic of protein post‐translational modifications (PTMs): Chemistry, mechanisms and evolution of protein regulation through covalent attachments
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DOI: 10.1002/bies.202300178
Abstract: Protein post‐translational modifications (PTMs) play a crucial role in all cellular functions by regulating protein activity, interactions and half‐life. Despite the enormous diversity of modifications, various PTM systems show parallels in their chemical and catalytic… read more here.
Keywords: chemistry; translational modifications; protein post; logic ... See more keywords
Short‐chain acyl post‐translational modifications in cancers: Mechanisms, roles, and therapeutic implications
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DOI: 10.1002/cac2.70048
Abstract: Post‐translational modifications (PTMs) play a pivotal role in epigenetic regulation and are key pathways for modulating protein functionality. PTMs involve the covalent attachment of distinct chemical groups, such as succinyl, crotonyl, and lactyl, at specific… read more here.
Keywords: short chain; translational modifications; post translational; chain acyl ... See more keywords
Recombinant Monoclonal Antibodies for Detecting the Tubulin Post-Translational Modifications Glutamylation and Lysine-40 Acetylation.
Sign Up to like & getrecommendations! Published in 2025 at "Cytoskeleton"
DOI: 10.1002/cm.70011
Abstract: Post-translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine-40 (K40) on α-tubulin… read more here.
Keywords: translational modifications; glutamylation; tubulin; post translational ... See more keywords
Fusaric Acid Induces DNA Damage and Post‐Translational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2) Cells
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DOI: 10.1002/jcb.26037
Abstract: Fusaric acid (FA), a common fungal contaminant of maize, is known to mediate toxicity in plants and animals; however, its mechanism of action is unclear. p53 is a tumor suppressor protein that is activated in… read more here.
Keywords: dna damage; post translational; translational modifications; hepg2 cells ... See more keywords
Thiol redox proteomics: Characterization of thiol-based post-translational modifications.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202200194
Abstract: Redox post-translational modifications on cysteine thiols (redox PTMs) have profound effects on protein structure and function, thus enabling regulation of various biological processes. Redox proteomics approaches aim to characterize the landscape of redox PTMs at… read more here.
Keywords: redox proteomics; translational modifications; redox ptms; post translational ... See more keywords
Beyond the model organism—Mechanistic analysis of protein post‐translational modifications is ready for all challengers
Sign Up to like & getrecommendations! Published in 2024 at "PROTEOMICS"
DOI: 10.1002/pmic.202300314
Abstract: A historic challenge for shotgun proteomics has been the requirement for high quality, simple, and nonredundant curated protein sequences in small .fasta text files. Due to the intrinsic informatic challenges and time required to assemble… read more here.
Keywords: mechanistic analysis; translational modifications; organism mechanistic; post translational ... See more keywords
Computational Approaches for Pathway‐Centric Analysis of Protein Post‐Translational Modifications
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DOI: 10.1002/pmic.70055
Abstract: Protein function is dynamically modulated by post‐translational modifications (PTMs). Many different types of PTMs can nowadays be identified and quantified at a large scale using mass spectrometry. It is well known that many PTMs have… read more here.
Keywords: translational modifications; analysis; protein; post translational ... See more keywords
Histone Post-Translational Modifications and Nucleosome Organisation in Transcriptional Regulation: Some Open Questions.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2017_58
Abstract: The organisation of chromatin is first discussed to conclude that nucleosomes play both structural and transcription-regulatory roles. The presence of nucleosomes makes difficult the access of transcriptional factors to their target sequences and the action… read more here.
Keywords: organisation; modifications nucleosome; post translational; open questions ... See more keywords
Predicting Post-Translational Modifications from Local Sequence Fragments Using Machine Learning Algorithms: Overview and Best Practices.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6406-2_19
Abstract: Here, we present two perspectives on the task of predicting post translational modifications (PTMs) from local sequence fragments using machine learning algorithms. The first is the description of the fundamental steps required to construct a… read more here.
Keywords: machine; machine learning; local sequence; post translational ... See more keywords
Cleavage and phosphorylation: important post-translational modifications of galectin-3
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DOI: 10.1007/s10555-017-9666-0
Abstract: As the unique chimeric member of the β-galactoside-binding protein family, galectin-3 is a multivalent and multifunctional oncogenic protein involved in multiple physiological and pathological processes, including cell growth, cell differentiation, cell adhesion, RNA splicing, cell… read more here.
Keywords: galectin; post translational; cleavage phosphorylation; translational modifications ... See more keywords
Regulation of Synaptic NMDA Receptor Activity by Post-Translational Modifications
Sign Up to like & getrecommendations! Published in 2025 at "Neurochemical Research"
DOI: 10.1007/s11064-025-04346-6
Abstract: NMDA receptors for the neurotransmitter glutamate are widely distributed in the central nervous system, playing important roles in brain development, function and plasticity. Alterations in their activity are also important mediators in neuropsychiatric and neurodegenerative… read more here.
Keywords: translational modifications; nmda receptor; post translational; regulation ... See more keywords