Fusaric Acid Induces DNA Damage and PostāTranslational Modifications of p53 in Human Hepatocellular Carcinoma (HepG2) Cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26037
Abstract: Fusaric acid (FA), a common fungal contaminant of maize, is known to mediate toxicity in plants and animals; however, its mechanism of action is unclear. p53 is a tumor suppressor protein that is activated in… read more here.
Keywords: dna damage; post translational; translational modifications; hepg2 cells ... See more keywords
Thiol redox proteomics: Characterization of thiol-based post-translational modifications.
Sign Up to like & getrecommendations! Published in 2023 at "Proteomics"
DOI: 10.1002/pmic.202200194
Abstract: Redox post-translational modifications on cysteine thiols (redox PTMs) have profound effects on protein structure and function, thus enabling regulation of various biological processes. Redox proteomics approaches aim to characterize the landscape of redox PTMs at… read more here.
Keywords: redox proteomics; translational modifications; redox ptms; post translational ... See more keywords
Histone Post-Translational Modifications and Nucleosome Organisation in Transcriptional Regulation: Some Open Questions.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2017_58
Abstract: The organisation of chromatin is first discussed to conclude that nucleosomes play both structural and transcription-regulatory roles. The presence of nucleosomes makes difficult the access of transcriptional factors to their target sequences and the action… read more here.
Keywords: organisation; modifications nucleosome; post translational; open questions ... See more keywords
Predicting Post-Translational Modifications from Local Sequence Fragments Using Machine Learning Algorithms: Overview and Best Practices.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6406-2_19
Abstract: Here, we present two perspectives on the task of predicting post translational modifications (PTMs) from local sequence fragments using machine learning algorithms. The first is the description of the fundamental steps required to construct a… read more here.
Keywords: machine; machine learning; local sequence; post translational ... See more keywords
Cleavage and phosphorylation: important post-translational modifications of galectin-3
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9666-0
Abstract: As the unique chimeric member of the Ī²-galactoside-binding protein family, galectin-3 is a multivalent and multifunctional oncogenic protein involved in multiple physiological and pathological processes, including cell growth, cell differentiation, cell adhesion, RNA splicing, cell… read more here.
Keywords: galectin; post translational; cleavage phosphorylation; translational modifications ... See more keywords
Significance of Mitochondrial Protein Post-translational Modifications in Pathophysiology of Brain Injury
Sign Up to like & getrecommendations! Published in 2017 at "Translational Stroke Research"
DOI: 10.1007/s12975-017-0569-8
Abstract: Mitochondria are complex organelles that undergo constant fusion and fission in order to adapt to the ever-changing cellular environment. The fusion/fission proteins, localized in the inner and outer mitochondrial membrane, play critical roles under pathological… read more here.
Keywords: fusion fission; translational modifications; brain injury; post translational ... See more keywords
An emerging role for the ribosome as a nexus for post-translational modifications.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2017.02.010
Abstract: The ribosome is one of life's most ancient molecular machines that has historically been viewed as a backstage participant in gene regulation, translating the genetic code across all kingdoms of life in a rote-like fashion.… read more here.
Keywords: role ribosome; translational modifications; post translational; emerging role ... See more keywords
The Chemical Biology of Reversible Lysine Post-translational Modifications.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.07.002
Abstract: Lysine (Lys) residues in proteins undergo a wide range of reversible post-translational modifications (PTMs), which can regulate enzyme activities, chromatin structure, protein-protein interactions, protein stability, and cellular localization. Here we discuss the "writers," "erasers," and… read more here.
Keywords: chemical biology; lysine; post translational; biology ... See more keywords
Evaluation of main post-translational modifications occurring in naturally generated peptides during the ripening of Spanish dry-cured ham.
Sign Up to like & getrecommendations! Published in 2020 at "Food chemistry"
DOI: 10.1016/j.foodchem.2020.127388
Abstract: Peptidyl post-translational modifications (PTMs) could influence the final quality of processed meat. In this study, the peptide oxidative phenomena in Spanish dry-cured ham (Biceps femoris muscle) was evaluated at different ripening times (9, 12, 15,… read more here.
Keywords: cured ham; post translational; dry cured; translational modifications ... See more keywords
A glimpse into the modulation of post-translational modifications of human-colonizing bacteria.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2016.11.005
Abstract: Protein post-translational modifications (PTMs) are a key bacterial feature that holds the capability to modulate protein function and responses to environmental cues. Until recently, their role in the regulation of prokaryotic systems has been largely… read more here.
Keywords: modifications human; human colonizing; post translational; modulation post ... See more keywords
Biochemical genesis of enzymatic and non-enzymatic post-translational modifications.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2021.101053
Abstract: Post-translational modifications (PTMs) alter protein structure, function, and localization and play a pivotal role in physiological and pathophysiological conditions. Many PTMs arise from endogenous metabolic intermediates and serve as sensors for metabolic feedback to maintain… read more here.
Keywords: post translational; biochemical genesis; non enzymatic; translational modifications ... See more keywords