A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24575-x
Abstract: Premature termination codons (PTCs) prevent translation of a full-length protein and trigger nonsense-mediated mRNA decay (NMD). Nonsense suppression (also termed readthrough) therapy restores protein function by selectively suppressing translation termination at PTCs. Poor efficacy of… read more here.
Keywords: readthrough; translational readthrough; small molecule; induces translational ... See more keywords
Robustness by intrinsically disordered C-termini and translational readthrough
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky778
Abstract: Abstract During protein synthesis genetic instructions are passed from DNA via mRNA to the ribosome to assemble a protein chain. Occasionally, stop codons in the mRNA are bypassed and translation continues into the untranslated region… read more here.
Keywords: translational readthrough; robustness intrinsically; disordered termini; termini translational ... See more keywords
Cellular Senescence limits Translational Readthrough.
Sign Up to like & getrecommendations! Published in 2021 at "Biology open"
DOI: 10.1242/bio.058688
Abstract: The origin and evolution of cancer cells is considered to be mainly fueled by DNA mutations. Although translation errors could also expand the cellular proteome, their role in cancer biology remains poorly understood. Tumor suppressors… read more here.
Keywords: translational readthrough; senescence; biology; cellular senescence ... See more keywords
A system for coordinated analysis of translational readthrough and nonsense-mediated mRNA decay
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173980
Abstract: The nonsense-mediated mRNA decay (NMD) pathway degrades mRNAs containing premature termination codons, limiting the expression of potentially deleterious truncated proteins. This activity positions the pathway as a regulator of the severity of genetic diseases caused… read more here.
Keywords: readthrough; system; translational readthrough; analysis ... See more keywords
Translational readthrough at F8 nonsense variants in the factor VIII B domain contributes to residual expression and lowers inhibitor association
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.281279
Abstract: In hemophilia A, F8 nonsense variants, and particularly those affecting the large factor VIII (FVIII) B domain that is dispensable for coagulant activity, display lower association with replacement therapy-related anti-FVIII inhibitory antibodies as retrieved from… read more here.
Keywords: expression; nonsense variants; domain; translational readthrough ... See more keywords