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Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2023.2192553
Abstract: RNA-binding proteins are essential regulators of RNA processing and function. Translational repression assays can be used to study how they interact with specific RNA sequences by insertion of such a consensus sequence into the 5’…
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Keywords:
rna binding;
consensus;
reporter;
rna ... See more keywords
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Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab510
Abstract: Abstract In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) govern translation of numerous transcripts during carbon catabolite repression. Here, Crc was shown to enhance Hfq-mediated translational repression of several…
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Keywords:
hfq;
pseudomonas aeruginosa;
translational repression;
hfq mediated ... See more keywords
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Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky038
Abstract: Abstract Response gene to complement-32 (RGC-32) activates cyclin-dependent kinase 1, regulates the cell cycle and is deregulated in many human tumours. We previously showed that RGC-32 expression is upregulated by the cancer-associated Epstein-Barr virus (EBV)…
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Keywords:
ebv;
cyclin dependent;
pumilio;
rgc ... See more keywords
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Published in 2022 at "PLoS ONE"
DOI: 10.1101/2022.03.06.483204
Abstract: Endoplasmic Reticulum (ER) stress, caused by the accumulation of misfolded proteins in the ER, elicits a homeostatic mechanism known as the Unfolded Protein Response (UPR). The UPR reprograms gene expression to promote adaptation to chronic…
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Keywords:
acute phase;
mrna;
translational repression;
phase ... See more keywords
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Published in 2021 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13139
Abstract: Translational repression is a conserved mechanism in miRNA-guided gene silencing. In plants, ARGONAUTE1 (AGO1), the miRNA effector, localizes in the cytoplasm for mRNA cleavage and at the endoplasmic reticulum (ER) for translational repression of target…
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Keywords:
endoplasmic reticulum;
inhibit mirna;
translational repression;
repression ... See more keywords
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1
Published in 2017 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-016-0407-3
Abstract: The small heat shock protein HSPB1 (Hsp27) is an ubiquitously expressed molecular chaperone able to regulate various cellular functions like actin dynamics, oxidative stress regulation and anti-apoptosis. So far disease causing mutations in HSPB1 have…
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Keywords:
rna;
rna binding;
disease;
translational repression ... See more keywords
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1
Published in 2021 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009813
Abstract: Translation of messenger RNAs (mRNAs) with premature termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of…
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Keywords:
gigyf2 eif4e2;
targets gigyf2;
translational repression;
nmd targets ... See more keywords