Animal to human translation: a systematic scoping review of reported concordance rates
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-019-1976-2
Abstract: BackgroundDrug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-called “translational failure”. As far as… read more here.
Keywords: scoping review; animal human; success; systematic scoping ... See more keywords
A potential new tool to enhance translational success rate in stroke research by backcrossing techniques in transgenic mice
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.343899
Abstract: Ischemic stroke is a leading disease of the central nervous system, frequently coupled to severe damage and dysfunction in patients. Animal models mimicking human stroke provide useful tools for studying the pathomechanisms (e.g., inflammation, neuroprotection,… read more here.
Keywords: potential new; new tool; enhance translational; tool enhance ... See more keywords