Characterisation of mexiletine’s translational therapeutic index for suppression of ischaemia-induced ventricular fibrillation in the rat isolated heart
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DOI: 10.1038/s41598-020-65190-y
Abstract: The ‘translational therapeutic index’ (TTI) is a drug’s ratio of nonclinical threshold dose (or concentration) for significant benefit versus threshold for adversity. In early nonclinical research, discovery and safety studies are normally undertaken separately. Our… read more here.
Keywords: index; translational therapeutic; ischaemia induced; mexiletine ... See more keywords