PET as a Translational Tool in Drug Development for Neuroscience Compounds
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DOI: 10.1002/cpt.2548
Abstract: In central nervous system drug discovery programs, early development of new chemical entities (NCEs) requires a multidisciplinary strategy and a translational approach to obtain proof of distribution, proof of occupancy, and proof of function in… read more here.
Keywords: translational tool; development; pet translational; drug development ... See more keywords
A Translational Tool to Facilitate Use of Apolipoprotein B for Clinical Decision-Making.
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DOI: 10.1093/clinchem/hvac161
Abstract: BACKGROUND Despite recent large-scale discordance studies showing definitively that atherosclerotic cardiovascular disease (ASCVD) risk correlates better with apolipoprotein B (apoB) than with low-density lipoprotein cholesterol (LDL-C), the latter remains the recommended metric for guiding lipid-lowering… read more here.
Keywords: translational tool; apob; facilitate use; ascvd risk ... See more keywords